Haematological and Coagulation Profiles of Uterine Leiomyoma Patients Attending Federal Medical Centre, Yenagoa, Bayelsa State, Nigeria
Beredugo Sylvanus, Seimokumo, Poumusu Harrison, Ilegbedion, Ikhide Godwin, Chukwuedo Judith Nkechiyelum, Amaihunwa, Kingsley Chukwuka, Zebedee, Loveday Udu
Abstract
Uterine leiomyomas (fibroids) are benign tumors that can have effects on haematological and coagulation parameters, particularly in those with menorrhagia. Evaluation of such change has bearings on clinical care and preoperative preparation. This study assessed selected haematological and coagulation profiles of uterine leiomyoma patients attending Federal Medical Centre, Yenagoa, Bayelsa State. A case-control design comprising 20 patients with uterine leiomyoma and 10 age-matched controls selected through a convenient sampling technique. Five millilitres of blood samples were drawn from each participant. Full blood count was analysed using a SYSMEX XP 300 haematology analyser, and activated partial thromboplastin time (APTT) and prothrombin time (PT) were assayed using a semi-automated coagulometer. Data analysis was carried out using SPSS version 10, and statistical significance was established at p<0.05. The finding was that uterine leiomyoma patients had significantly higher mean packed cell volume (PCV: 35.40 ± 2.81), haemoglobin (Hb: 12.14 ± 1.41), red blood cell count (RBC: 4.68 ± 0.82), lymphocytes (51.15 ± 10.67), mean corpuscular volume (MCV: 81.15 ± 8.20), mean corpuscular haemoglobin (MCH: 27.40 ± 4.20), and mean corpuscular haemoglobin concentration (MCHC: 31.81 ± 1.90) compared to the control (PCV: 31.45 ± 2.70, Hb: 10.69 ± 1.48, RBC: 3.78 ± 0.58,
Keywords
; Uterine leiomyoma
fibroid
Prothrombin time (PT)
Activated partial thromboplastin
References
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10760296241286514.https://doi.org/10.1177/10760296241286514
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of Uterine Fibroids in Nnewi, Nigeria: A 5. year Review. Annals of medical and health
sciences research, 2(2), 114-118
Akinola, L. A., Okohue, J., Ikechebelu, J., Alabi, C. O., & Olumodeji, A. M. (2021). Approach to
Management of Submucous Fibroids by Gynaecological Endoscopy Surgeons/Trainees in
Nigeria. African Journal of Reproduction and Gynaecological Endoscopy, 6(1), 1-9.
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uterine fibroids: A systematic review. BJOG: An International Journal of Obstetrics &
Gynaecology, 124(10), 1501–1512. https://doi.org/10.1111/1471-0528.14640.
Baird, D. D., Hill, M. C., Schectman, J. M., & Hollis, B. W. (2013). Vitamin D and the risk of
uterine fibroids. Epidemiology, 24(3), 447–453.
Vitale, S. G., Riemma, G., Ciebiera, M., & Cianci, S. (2020). Hysteroscopic treatment of
submucosal fibroids in perimenopausal women: When, why and how? Climacteric, 23,
355–359.
Marsh, E. E., Al-Hendy, A., Kappus, D., Galitsky, A., Stewart, E. A., & Kerolous, M. (2018).
Burden, prevalence, and treatment of uterine fibroids: A survey of US women. Journal of
Women’s Health, 27(11), 1359–1367. https://doi.org/10.1089/jwh.2018.707
Yang, Q., & Al-Hendy, A. (2023). Update on the role and regulatory mechanism of extracellular
matrix in the pathogenesis of uterine fibroids. International Journal of Molecular Sciences,
24(6), 5778. https://doi.org/10.3390/ijms24065778
Abdelmtalab, M. A., Tahir, O., Hussein, K., & Badawi, K. (2020). Anatomical locations of uterine
fibroids in Sudanese women. Anatomy Journal of Africa, 9(1), 1701-1706.
Don, E.?E., Middelkoop, M., Hehenkamp, W.?J.?K.(2023). Endometrial Angiogenesis of Abnormal
Uterine Bleeding and Infertility in Patients with Uterine Fibroids: A Systematic Review.
International Journal of Molecular Sciences, 24(8), 7011. doi:10.3390/ijms24087011.
Gayathre, S. P., & Sivakumar, T. (2021). Giant uterine fibroid: a rare differential diagnosis for an
abdominopelvic mass. International Surgery Journal, 8(11), 3475-3478.
Mathew, R. P., Francis, S., Jayaram, V., & Anvarsadath, S. (2021). Uterine leiomyomas revisited
with review of literature. Abdominal Radiology, 46(10), 4908-4926.
Tu, W., Yano, M., Schieda, N., Krishna, S., Chen, L., Gottumukkala, R. V., & Alencar, R. (2023).
Smooth Muscle Tumors of the Uterus at MRI: Focus on Leiomyomas and FIGO
Classification. RadioGraphics, 43(6), e220161.
De Bruyn, C., Ceusters, J., Vanden Brande, K., Timmerman, S., Froyman, W., Timmerman, D. &
Van den Bosch, T. (2023). Ultrasound features using MUSA terms and definitions in
uterine sarcoma and leiomyoma: retrospective cohort study. Ultrasound in Obstetrics &
Gynecology.
Galindo, L. J., Hernández-Beeftink, T., Salas, A., Jung, Y., Reyes, R., de Oca, F. M., ... & Almeida,
T. A. (2018). HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas.
Gynecologic Oncology, 150(3), 562–568. https://doi.org/10.1016/j.ygyno.2018.07.007
Shtykalova, S. V., Egorova, A. A., Maretina, M. A., et al. (2021). Molecular genetic basis and
prospects of gene therapy of uterine leiomyoma. Russian Journal of Genetics, 57, 1002–
https://doi.org/10.1134/S1022795421090118
Faustino, F., Martinho, M., Reis, J., & Águas, F. (2017). Update on medical treatment of uterine
fibroids. European Journal of Obstetrics & Gynecology and Reproductive Biology, 216,
61–68. https://doi.org/10.1016/j.ejogrb.2017.06.047
Protic, O., Toti, P., Islam, M. S., Occhini, R., Giannubilo, S. R., Catherino, W. H., ... & Ciarmela,
P. (2016). Possible involvement of inflammatory/reparative processes in the development
of
uterine
fibroids.
Cell
and
Tissue
Research,
364(2),
415–427.
https://doi.org/10.1007/s00441-015-2324-3
Zannotti, A., Greco, S., Pellegrino, P., Giantomassi, F., Delli Carpini, G., & Goteri, G. (2021).
Macrophages and immune responses in uterine fibroids. Cells, 10(5), 982.
https://doi.org/10.3390/cells10050982.
Jeng, C. J., Long, C. Y., & Chuang, L. T. (2020). Comparison of magnetic resonance-guided high-
intensity focused ultrasound with uterine artery embolization for the treatment of uterine
myoma: A systematic literature review and meta-analysis. Taiwanese Journal of Obstetrics
and Gynecology, 59(5), 691-697.
Yang, Q., Ciebiera, M., Bariani, M. V., Ali, M., Elkafas, H., Boyer, T. G., & Al-Hendy, A. (2022).
Comprehensive review of uterine fibroids: Developmental origin, pathogenesis, and
treatment. Endocrine Reviews, 43, 678–719. https://doi.org/10.1210/endrev/bnab039
Singh, S., Kumar, P., Rathore, S. S., Singh, Y., & Garg, N. (2023). Contemporary approaches in
the management of uterine leiomyomas. European Journal of Obstetrics & Gynecology
and Reproductive Biology.
Stanescu, A. D., Loghin, M. G., Ples, L., Balan, D. G., Paunica, I., & Balalau, O. D. (2021).
Therapeutic approach of uterine leiomyoma; choosing the most appropriate surgical
option. Journal of Clinical and Investigative Surgery, 6(1), 1-5.
Giuliani, E., As-Sanie, S., & Marsh, E. E. (2020). Epidemiology and management of uterine
fibroids.
International
Journal
of
Gynecology
&
Obstetrics,
149(1),
3–9.
https://doi.org/10.1002/ijgo.13102
Ali, M., Sara, A. R., & Al-Hendy, A. (2021). Elagolix in the treatment of heavy menstrual bleeding
associated with uterine fibroids in premenopausal women. Expert Review of Clinical
Pharmacology, 14(4), 427–437. https://doi.org/10.1080/17512433.2021.1900726.
Ono, Y., Hidaka, T., & Fukuta, K. (2014). A case of myomatous erythrocytosis syndrome
associated with a large uterine leiomyoma. Case Reports in Obstetrics and Gynecology,
2014, 602139. https://doi.org/10.1155/2014/602139.
De Boer, J. P., Velders, G., Aliredjo, R., Scheenjes, E., & Flinsenberg, T. W. H. (2017).
Polycythaemia in a patient with uterus myomatosus. Nederlands Tijdschrift Voor
Geneeskunde, 161, D1161–D1161.
Ottolina, J., Bartiromo, L., Dolci, C., Salmeri, N., Schimberni, M., Villanacci, R., .& Candiani, M.
(2020). Assessment of coagulation parameters in women affected by endometriosis:
validation study and systematic review of the literature. Diagnostics, 10(8), 567..
https://doi.org/10.3390/diagnostics10080567.
Kobayashi, T., Hirayama, M., Nogami, M., Meguro, K., Iiduka, M., Foidart, J. M., ... & Harada,
T. (2024). Impact of estetrol combined with drospirenone on blood coagulation and
fibrinolysis in patients with endometriosis: a multicenter, randomized, open-label, active-
controlled, parallel-group study. Clinical and Applied Thrombosis/Hemostasis, 30,
10760296241286514.https://doi.org/10.1177/10760296241286514
Keshta, M. S., Ghanem, M., Alsayed, Y., Zeidan, O., Khorma, Y., Jeddy, R., ... & Jeddy, R. (2024).
A multicenter retrospective cohort study assessing the incidence of anemia in patients
associated with uterine fibroids. Cureus, 16(9). https://doi.org/10.7759/cureus.69899.
Covali, R., Socolov, D., Pavaleanu, I., Cara?uleanu, A., & Socolov, R. (2020). Platelet indices in
uterine leiomyoma compared with other major gynecological diseases. Journal of
Advances
in
Medicine
and
Medical
Research,
32(24),
164–176.
https://doi.org/10.9734/JAMMR/2020/v32i2430764
Ciebiera, M., Esfandyari, S., Siblini, H., Prince, L., Elkafas, H., Wojty?a, C., ... & Ali, M. (2021).
Nutrition in gynecological diseases: Current perspectives. Nutrients, 13, 1178.
https://doi.org/10.3390/nu13041178
Guyton, A. C., & Hall, J. E. (2006). Hemostasis and blood coagulation. Textbook of medical
physiology, 1, 419-429.
Mahlangu, J., Diop, S., & Lavin, M. (2024). Diagnosis and treatment challenges in lower resource
countries: State-of-the-art. Haemophilia, 30, 78–85. https://doi.org/10.1111/hae.14956
Ezeama, C. O., Ikechebelu, J. I., Obiechina, N. J., & Ezeama, N. N. (2012). Clinical Presentation
of Uterine Fibroids in Nnewi, Nigeria: A 5. year Review. Annals of medical and health
sciences research, 2(2), 114-118
Akinola, L. A., Okohue, J., Ikechebelu, J., Alabi, C. O., & Olumodeji, A. M. (2021). Approach to
Management of Submucous Fibroids by Gynaecological Endoscopy Surgeons/Trainees in
Nigeria. African Journal of Reproduction and Gynaecological Endoscopy, 6(1), 1-9.
Iwuoha EC, Uwaegbulam CE, Eni I,
