JOURNAL OF BIOLOGY AND GENETIC RESEARCH (JBGR )

E-ISSN 2545-5710
P-ISSN 2695-222X
VOL. 10 NO. 2 2024
DOI: 10.56201/jbgr.v10.no2.2024.pg15.21


Melanin: Nature’s Gift Against Skin Cancer

Awah Chukwuma Quintus


Abstract


The pigment melanin is the gift of nature that protects the skin from damage to DNA caused by ultraviolet (UV) rays. The biochemistry of the process is exciting and individuals whose skin have this pigment should cherish and protect it. This article explains how melanin is produced in the body, its types and the biochemical activities that show how it shields individuals from developing skin cancer. As this knowledge is provided; the article posits that skin bleaching is an uninformed act. An expository presentation of the topic is done which is aimed at enhancing understanding of it. There is a plethora of scientific knowledge available on the beneficial properties of melanin; however this knowledge has regrettably not benefitted a good number of individuals in the public health community. Thus, this piece will hopefully raise awareness on the priceless importance of melanin and discourage acts like skin bleaching that distort its benefits.


keywords:

Melanin; Bleaching; Skin Cancer


References:


1). Maranduca MA, Branisteanu D, Serban DN, Branisteanu DC, Stoleriu G, Manolache N, Serban
IL (2019): Synthesis and physiological implications of melanic pigments. Oncol Lett. 2019
May;17(5):4183-4187.

2). Fernandez-Flores A, Saeb-Lima M, Cassarino DS (2019): Histopathology of aging of the hair
follicle. J Cutan Pathol. 2019 Jul;46(7):508-519.

3). Starace M, Alessandrini A, Brandi N, Piraccsini BM. (2019): Use of Nail Dermoscopy in the
Management of Melanonychia: Review. Dermatol Pract Concept. 2019 Jan;9(1):38-43.
D'Alba L, Shawkey MD (2019): Melanosomes: Biogenesis, Properties, and Evolution of an
Ancient Organelle. Physiol Rev. 2019 Jan 01;99(1):1-19.

5). Greggory S. LaBerge, Eric Duvall, Zachary Grasmick, Kay Haedicke, Ajela Galan, Jesse
Leverett, Sudhr Baswan, Sunghan Yim and John Pawelek. (2020): Recent Advances in Studies of
Skin Color and Skin Cancer. J Biol Med, 2020 Mar; 93(1): 69-80. Published online: 2020 Mar 27
6). Pfeifer, G. P., and Besaratinia, A. (2012) UV wavelength-dependent DNA damage and human
non-melanoma and melanoma skin cancer. Photochem. Photobiol. Sci. 11, 90–97
7). Cestari, T., and Buster, K. (2017) Photoprotection in specific populations: children and people
of color. J. Am. Acad. Dermatol. 76 (3S1), S110–S121
8). Gloster, H. M. J., Jr., and Neal, K. (2006) Skin cancer in skin of color. J. Am. Acad. Dermatol.
55, 741–760, quiz 761–764
National
Institute
for
Communicable
Diseases:
National
cancer
registry.
http://www.nicd.ac.za/index.php/centres/national-cancer-registry/

10). Norval, M., Kellett, P., and Wright, C. Y. (2014) The incidence and body site of skin cancers
in the population groups of South Africa. Photodermatol. Photoimmunol. Photomed. 30, 262–265

11). Del Bino, S., Ito, S., Sok, J., Nakanishi, Y., Bastien, P., Wakamatsu, K., and Bernerd, F.
(2015) Chemical analysis of constitutive pigmentation of human epidermis reveals constant
eumelanin to pheomelanin ratio. Pigment Cell Melanoma Res. 28, 707–717

12). Kaidbey, K. H., Agin, P. P., Sayre, R. M., and Kligman, A. M. (1979) Photoprotection by
melanin–a comparison of black and Caucasian skin. J. Am. Acad. Dermatol. 1, 249–260 11

13). Francisco Solano (2020): Photoreceptio and Skin Pigmentation: Melanin-Related Molecules
and Other New Agents Obtained From Natural Sources. Molecules 2020, 25(7), 1537

14).Madronich, S.; McKenzie, R.L.; Björn, L.O.; Caldwell, M.M (1998): Changes in biologically
active ultraviolet radiation reaching the Earth’s surface. J. Photochem. Photobiol. B 1998, 46,
5–19.

15). D’Orazio, J.; Jarrett, S.; Amaro-Ortiz, A.; Scott, T. (2013): UV radiation and the skin. Int. J.
Mol. Sci. 2013, 14, 12222–12248.

16). Premi, S.; Wallisch, S.; Mano, C.M.; Weiner, A.B.; Bacchiocchi, A.; Wakamatsu, K.;
Bechara, E.J.H.; Halaban, R.; Douki, T.; Brash, D.E. (2015): Photochemistry. Chemiexcitation of
melanin derivatives induces DNA photoproducts long after UV exposure. Science 2015, 347, 842–
17). Solano, F. (2016): Photoprotection versus photodamage: Updating an old but still unsolved
controversy about melanin. Polymer Intern. 2016, 65, 1276–1287.

18). Fisher, J.M.; Fisher, D.E. (2008): From suntan to skin cancers: Molecular pathways and
prevention strategies. Targ. Oncol. 2008, 3, 41–44.

19). W.Korytowski et al (1986): Reaction of superoxide anions with melains: electron spin
resonance and spin trapping studies. Biochim. Biophys. Acta 1986.

20). W. Korytowski (1985): Mechanism of dismutation od superoxide produced during
autoxidation of melanin pigments. Biochem. Biophys. Res. Commun. 1985

21). J,M. Wood et al (1991): Studies on the reactions between human tyrosinase, superoxide anion
hydrogen peroxide and thiols. Biochem. Biophys. Acta.1991

22). A.M. Potts et al (1976): The affinity of melanin for inorganic ions. Exp. Eye Res. 1976.

23). R. Salceda et al (2000): Calcium uptake, release and ryanodine binding in melanosomes from
retinal pigment epithelium. Cell Calcium. 2000
24). M. Panayiotidis et al. (1999): Glucose oxidase-produced H2O2 induces Ca2+-dependent DNA
damage in human peripheral blood lymphocytes. Free Radic. Biol. Med. 1999.
25). A. Barbouti et al. (2001): Intracellular iron, but not copper, plays a critical role in hydrogen
peroxide-induced DNA damage. Free Radic. Biol. Med. 2001.
26). J. Tang et al (2000): Mechanisms of [Ca2+]i elevation by H2O2 in islets of rats. Life Sci. 2000
27). J. Ancans et al (2001): Melanosomal pH, pink locus protein and their roles in melanogenesis.
J. Invest. Dermatol. 2001
28). N.P. Singh et al (1998): A simple technique for quantitation of low levels of DNA damage in
individual cells. Exp. Cell Res. 1988
29). F. Furukawa et al (1988): Characterization and practical benefits of keratinocytes cultured in
strontium-containing serum-free medium. J. Invest. Dermatol. 1988
30). E. Wenczl et al (1998): (Pheo)melanin photosensitizes UVA-induced DNA damage in
cultured human melanocytes. J. Invest. Dermatol. 1998.
31). J. Ancans et al. (2001): Melanosomal pH controls rate of melanogenesis,
eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells.
Exp. Cell Res. 2001

32). K.U. Schallreuter et al (1986): The role of calcium in the regulation of free radical reduction
by thioredoxin reductase at the surface of the skin. J. Inorg. Biochem. 1986
33). K.U. Schallreuter et al. (1989): EF-hands calcium binding regulates the thioredoxin
reductase/thioredoxin electron transfer in human keratinocytes. Biochem. Biophys. Res. Commun.
34). C. Gitler et al (2002): Calcium-dependent oxidation of thioredoxin during cellular growth
initiation. Biochem. Biophys. Res. Commun. 2002
35). K.U. Schallreuter et al (2001): Thioredoxin reductase—Its role in epidermal redox status. J.
Photochem. Photobiol. B. 2001
36). A.B. Scoltock et al (2000): A selective requirement for elevated calcium in DNA degradation,
but not early events in anti-Fas-induced apoptosis. J. Biol. Chem. 2000
37). G. Ermak et al (2002): Calcium and oxidative stress: from cell signaling to cell death. Mol.
Immunol. 2002.
38). K.U. Schallreuter et al (1999): The importance of L-phenylalanine transport and its autocrine
turnover to L-tyrosine for melanogenesis in human epidermal melanocytes. Biochem. Biophys.
Res. Commun. 1999.
39). Comparative transcriptome elucidates key genes and pathways related to golden phenotype
of Crassostrea gigas. 2024, Comparative Biochemistry and Physiology - Part D: Genomics and
Proteomics.

40). Emma K.T. Benn, Andrew Alexis, Nihal Mohamed, Yan-Hong-Wang, Ikhlas A. Khan, Bian
Liu (2016): Skin Bleaching and Dermatologic Health of African and Afro-Carribean Populations
in the US: New Directions for Methodologically Rigorous, Multidisciplinary and Culturally
Sensitive Research. Dermatology and Therapy. 11 November 2016.

41). Tse, TW (2010): Hydroquinone for skin lightening: safety profile, duration of use and when
should we stop?. The Journal of Dermatological Treatment. 21 (5): 272–5. September 2010.

42). Ebanks Jody P, Wickett R. Randall, Boisy Raymond E (2009): Mechanisms Regulating Skin
Pignemtation: The Rise and Fall of Complexio Colouration. Int J Mol Sci. 10(9):4066-4087.


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