References
Akinso, O., Adhikari, A., Yin, J., Chopak-Foss, J., & Shah, G. (2023). Childhood Asthma- Management Practices in Rural Nigeria: Exploring the Knowledge, Attitude, and Practice of Caregivers in Oyo State. Children, 10(6), 1043. Arash Salahshouri, Parvaneh Raisi-Philabadi, Ghanbari, S., Stein, L., & Marzieh Araban. (2024). Using the health beliefs model to implement mobile puberty health education in Iranian adolescent boys: a randomized controlled trial. Frontiers in Public Health, 12. https://doi.org/10.3389/fpubh.2024.1175262 Averina, M., Brox, J., Huber, S., Furberg, A.-S., & Sørensen, M. (2019). Serum perfluoroalkyl substances and risk of asthma and various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway. Environmental Research, 169, 114–121. https://doi.org/10.1016/j.envres.2018.11.005 Bhavic Garrach, Kamlesh Kalidas, & Matlawene John Mpe. (2024). Asthma control among teenagers attending the respiratory outpatient clinic of an academic hospital in Pretoria, South Africa. Journal of the Pan African Thoracic Society, 5(2), 62–68. https://doi.org/10.25259/jpats_4_2024 Bønnelykke, K., Sleiman, P., Nielsen, K., Kreiner-Møller, E., Mercader, J. M., Belgrave, D., den Dekker, H. T., Husby, A., Sevelsted, A., Faura-Tellez, G., Mortensen, L. J., Paternoster, L., Flaaten, R., Mølgaard, A., Smart, D. E., Thomsen, P. F., Rasmussen, M. A., Bonàs- Guarch, S., Holst, C., & Nohr, E. A. (2014). A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nature Genetics, 46(1), 51–55. https://doi.org/10.1038/ng.2830 Bousquet, J., Mantzouranis, E., Cruz, A. A., Aït-Khaled, N., Baena-Cagnani, C. E., Bleecker, E. R., Brightling, C. E., Burney, P., Bush, A., Busse, W. W., Casale, T. B., Chan-Yeung, M., Chen, R., Chowdhury, B., Chung, K. F., Dahl, R., Drazen, J. M., Fabbri, L. M., Holgate, S. T., & Kauffmann, F. (2010). Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma. Journal of Allergy and Clinical Immunology, 126(5), 926–938. https://doi.org/10.1016/j.jaci.2010.07.019 British Red Cross. (2025). First aid for someone who is having an asthma attack. BRC Site Name. https://www.redcross.org.uk/first-aid/learn-first-aid/asthma-attack Chatkin, J., Correa, L., & Santos, U. (2021). External Environmental Pollution as a Risk Factor for Asthma. Clinical Reviews in Allergy & Immunology, 62(1), 72–89. https://doi.org/10.1007/s12016-020-08830-5 Chen, W., Safari, A., FitzGerald, J. M., Sin, D. D., Tavakoli, H., & Sadatsafavi, M. (2019). Economic burden of multimorbidity in patients with severe asthma: a 20-year population- based study. Thorax, 74(12), 1113–1119. https://doi.org/10.1136/thoraxjnl-2019-213223 Chun, C. (2022). Global Strategy for Asthma Management and Prevention: Interpretation of the Updates in 2022. Chinese General Practice, 25(35), 4355. https://doi.org/10.12114/j.issn.1007-9572.2022.0554 Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., Boulet, L.-P., Brightling, C., Chanez, P., Dahlen, S.-E., Djukanovic, R., Frey, U., Gaga, M., Gibson, P., Hamid, Q., & Jajour, N. N. (2013). International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. European Respiratory Journal, 43(2), 343–373. https://doi.org/10.1183/09031936.00202013 P- ISSN 2695-2165 Crossingham, I., Turner, S., Ramakrishnan, S., Fries, A., Gowell, M., Yasmin, F., Richardson, R., Webb, P., O’Boyle, E., & Hinks, T. S. (2021). Combination fixed-dose beta agonist and steroid inhaler as required for adults or children with mild asthma. Cochrane Database of Systematic Reviews, 2021(5). https://doi.org/10.1002/14651858.cd013518.pub2 Desalu, O. O., Adeoti, A. O., Ojuawo, O. B., Aladesanmi, A. O., Oguntoye, M. S., Afolayan, O. J., Bojuwoye, M. O., & Fawibe, A. E. (2021). Urban–Rural Differences in the Epidemiology of Asthma and Allergies in Nigeria: A Population-Based Study. Journal of Asthma and Allergy, 14, 1389–1397. https://doi.org/10.2147/JAA.S333133 Dharmage, S. C., Perret, J. L., & Custovic, A. (2019). Epidemiology of Asthma in Children and Adults. Frontiers in Pediatrics, 7(246). https://doi.org/10.3389/fped.2019.00246 Dierick, B. J. H., van der Molen, T., Flokstra-de Blok, B. M. J., Muraro, A., Postma, M. J., Kocks, J. W. H., & van Boven, J. F. M. (2020). Burden and Socioeconomics of asthma, Allergic rhinitis, Atopic Dermatitis and Food Allergy. Expert Review of Pharmacoeconomics & Outcomes Research, 20(5), 437–453. https://doi.org/10.1080/14737167.2020.1819793 Donohue, J. F., Kerwin, E., Sethi, S., Haumann, B., Pendyala, S., Dean, L., Barnes, C. N., Moran, E. J., & Crater, G. (2019). Revefenacin, a once-daily, lung-selective, long-acting muscarinic antagonist for nebulized therapy: Safety and tolerability results of a 52-week phase 3 trial in moderate to very severe chronic obstructive pulmonary disease. Respiratory Medicine, 153, 38–43. https://doi.org/10.1016/j.rmed.2019.05.010 Duminda Yasaratne, Nur Sabrina Idrose, & Dharmage, S. C. (2023). Asthma in developing countries in the Asia‐Pacific Region . Respirology, 28(11), 992–1004. https://doi.org/10.1111/resp.14590 Ehrlich, V., Bil, W., Vandebiel, R., Granum, B., Luijten, M., Lindeman, B., Grandjean, P., Kaiser, A.-M., Hauzenberger, I., Hartmann, C., Gundacker, C., & Uhl, M. (2023). Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances . Environmental Health, 22(1). https://doi.org/10.1186/s12940-022-00958-5 El-Husseini, Z. W., Gosens, R., Dekker, F., & Koppelman, G. H. (2020). The genetics of asthma and the promise of genomics-guided drug target discovery. The Lancet. Respiratory Medicine, 8(10), 1045–1056. https://doi.org/10.1016/S2213-2600(20)30363-5 Figueiredo, I. A. D., Ferreira, S. R. D., Fernandes, J. M., Silva, B. A. da, Vasconcelos, L. H. C., & Cavalcante, F. A. (2023). A review of the pathophysiology and the role of ion channels on bronchial asthma. Frontiers in Pharmacology, 14, 1236550. https://doi.org/10.3389/fphar.2023.1236550 Finkelstein, E. A., Lau, E., Doble, B., Ong, B., & Koh, M. S. (2021). Economic burden of asthma in Singapore. BMJ Open Respiratory Research, 8(1), e000654. https://doi.org/10.1136/bmjresp-2020-000654 Gaylord, A., Berger, K. I., Naidu, M., Attina, T. M., Gilbert, J., Koshy, T. T., Han, X., Marmor, M., Shao, Y., Giusti, R., Goldring, R. M., Kannan, K., & Trasande, L. (2019). Serum perfluoroalkyl substances and lung function in adolescents exposed to the World Trade Center disaster. Environmental Research, 172, 266–272. Glanz, K., Rimer, B., & Viswanath, K. (2015). Health Behavior: Theory, Research, and Practice (5th ed.). John Wiley & Sons. Global Asthma Network. (2022). The Global Asthma Report 2022. The International Journal of Tuberculosis and Lung Disease, 26(1), 1–104. https://doi.org/10.5588/ijtld.22.1010 P- ISSN 2695-2165 Global Asthma Network . (2024). The Global Asthma Report 2025: Patient Stories. Cloud.microsoft. https://sway.cloud.microsoft/mFGrHGIgFPFGI8eH Global Initiative for Asthma. (2019). Pocket guide for asthma management and prevention. 2019, pp. 1–32. Global Initiative for Asthma - GINA. http://www.ginasthma.org/ Global Initiative for Asthma. (2022). Global Strategy for Asthma Management and Prevention. Goh, L. H., Siah, C. J. R., Tam, W. W. S., Tai, E. S., & Young, D. Y. L. (2022). Effectiveness of the chronic care model for adults with type 2 diabetes in primary care: a systematic review and meta-analysis. Systematic Reviews, 11(1). Goldin, J., Hashmi, M. F., & Cataletto, M. E. (2024). Asthma. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK430901/ Grossman, N. L., Ortega, V. E., King, T. S., Bleecker, E. R., Ampleford, E. A., Bacharier, L. B., Cabana, M. D., Cardet, J. C., Carr, T. F., Castro, M., Denlinger, L. C., Denson, J. L., Fandino, N., Fitzpatrick, A. M., Hawkins, G. A., Holguin, F., Krishnan, J. A., Lazarus, S. C., Nyenhuis, S. M., & Phipatanakul, W. (2019). Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials. The Journal of Allergy and Clinical Immunology, 144(6), 1524–1533. https://doi.org/10.1016/j.jaci.2019.08.033 Hammad, H., & Lambrecht, B. N. (2021). The basic immunology of asthma. Cell, 184(6), 1469– 1485. https://doi.org/10.1016/j.cell.2021.02.016 Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020). Oxidative Stress in Cancer. Cancer Cell, 38(2), 167–197. https://doi.org/10.1016/j.ccell.2020.06.001 Jackson-Browne, M. S., Eliot, M., Patti, M., Spanier, A. J., & Braun, J. M. (2020). PFAS (per- and polyfluoroalkyl substances) and asthma in young children: NHANES 2013–2014. International Journal of Hygiene and Environmental Health, 229, 113565. Kadu, M. K., & Stolee, P. (2015). Facilitators and barriers of implementing the chronic care model in primary care: a systematic review. BMC Family Practice, 16(1). Karimi, P., Peters, K. O., Bidad, K., & Strickland, P. T. (2015). Polycyclic aromatic hydrocarbons and childhood asthma. European Journal of Epidemiology, 30(2), 91–101. https://doi.org/10.1007/s10654-015-9988-6 Kouzegaran, S., Samimi, P., Ahanchian, H., Khoshkhui, M., & Behmanesh, F. (2018). Quality of Life in Children with Asthma versus Healthy Children. Open Access Macedonian Journal of Medical Sciences, 6(8), 1413–1418. https://doi.org/10.3889/oamjms.2018.287 Kvalem, H. E., Nygaard, U. C., Lødrup Carlsen, K. C., Carlsen, K. H., Haug, L. S., & Granum, B. (2020). Perfluoroalkyl substances, airways infections, allergy and asthma related health outcomes – implications of gender, exposure period and study design. Environment International, 134, 105259. https://doi.org/10.1016/j.envint.2019.105259 Lambrecht, B. N., & Hammad, H. (2015). The Immunology of Asthma. Nature Immunology, 16(1), 45–56. https://doi.org/10.1038/ni.3049 Lombardi, C., Berti, A., & Cottini, M. (2022). The emerging roles of eosinophils: Implications for the targeted treatment of eosinophilic-associated inflammatory conditions. Current Research in Immunology, 3, 42–53. https://doi.org/10.1016/j.crimmu.2022.03.002 Lupu, V. V., Jechel, E., Fotea, S., Morariu, I. D., Starcea, I. M., Azoicai, A., Mocanu, A., Mitrofan, E. C., Lupu, A., Munteanu, D., Badescu, M. C., Cuciureanu, M., & Ioniuc, I. (2023). Current Approaches in the Multimodal Management of Asthma in Adolescents— From Pharmacology to Personalized Therapy. Biomedicines, 11(9), 2429. https://doi.org/10.3390/biomedicines11092429 P- ISSN 2695-2165 Maduka, U. D., Joy, E. N., Tagbo, O., & Obinna Emmanuel, O. (2021). Burden of childhood and adolescence Asthma in Nigeria: Disability adjusted life years. Paediatric Respiratory Reviews. https://doi.org/10.1016/j.prrv.2021.07.004 Mansur, A. H., & Prasad, N. (2023). Management of difficult-to-treat asthma in adolescence and young adults. Breathe, 19(1), 220025. https://doi.org/10.1183/20734735.0025-2022 Manuel, S.-S., & Luis, G.-M. (2021). Nutrition, Obesity and Asthma Inception in Children. The Role of Lung Function. Nutrients, 13(11), 3837. https://doi.org/10.3390/nu13113837 Mathiazhakan, U., & Abirami, P. (2023). Impact of Caregiver’s Burden of Children with Asthma: A Systematic Review. International Journal of Nutrition, Pharmacology, Neurological Diseases, 13(2), 89. https://doi.org/10.4103/ijnpnd.ijnpnd_60_22 MedlinePlus. (2016). Unconsciousness - first aid: MedlinePlus Medical Encyclopedia. Medlineplus.gov. https://medlineplus.gov/ency/article/000022.htm Mersha, T. B., Qin, K., Beck, A. F., Ding, L., Huang, B., & Kahn, R. S. (2021). Genetic ancestry differences in pediatric asthma readmission are mediated by socioenvironmental factors. Journal of Allergy and Clinical Immunology, 148(5), 1210-1218.e4. https://doi.org/10.1016/j.jaci.2021.05.046 Murrison, L. B., Brandt, E. B., Myers, J. B., & Hershey, G. K. K. (2019). Environmental exposures and mechanisms in allergy and asthma development. Journal of Clinical Investigation, 129(4), 1504–1515. https://doi.org/10.1172/jci124612 National Asthma Education and Prevention Program (National Heart, Lung, and Blood Institute). (1997). Expert Panel Report 2: guidelines for the diagnosis and management of asthma. DIANE Publishing. NATIONAL INSTITUTES OF HEALTH-National Heart, Lung, and Blood Institute. (2002). GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION NATIONAL INSTITUTES OF HEALTH National Heart, Lung, and Blood Institute. https://ginasthma.org/wp-content/uploads/2019/01/2002-GINA.pdf Nicolas van Larebeke, Koppen, G., Sam De Craemer, Colles, A., Liesbeth Bruckers, Elly Den Hond, Govarts, E., Morrens, B., Schettgen, T., Remy, S., Dries Coertjens, Nawrot, T., Nelen, V., Baeyens, W., & Greet Schoeters. (2023). Per- and polyfluoroalkyl substances and immune system-related diseases: results from the Flemish Environment and Health Study 2008–2014. Environmental Sciences Europe, 35(1). https://doi.org/10.1186/s12302-023-00731-6 Nnadozie, E. C., Igwe, C. N., Austin, M. V., Obi, C. G., Eneh, S. C., Innocent, D. C., Onukansi, F. O., & Ojo, T. O. (2025). Asthma Treatment Outcomes and Trends: A Six-Year Retrospective Study at a Federal Medical Centre in South-Eastern Nigeria. Research Square. https://doi.org/10.21203/rs.3.rs-6138166/v1 Nwaru, B. I., Ekström, M., Hasvold, P., Wiklund, F., Telg, G., & Janson, C. (2020). Overuse of short-acting β2-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme. European Respiratory Journal, 55(4). https://doi.org/10.1183/13993003.01872-2019 Oloniniyi, I. O., Aloba, O. O., Akinsulore, A., Adeniyi, B. O., Oginni, O. A., Erhabor, G. E., & Makanjuola, R. O. (2019). Economic Cost of Asthma and Psychiatric Morbidity in Nigerian Patients with Asthma. West African Journal of Medicine, 36(3), 267–273. http://www.ncbi.nlm.nih.gov/pubmed/31622490 Omoike, O. E., Pack, R. P., Mamudu, H. M., Liu, Y., Strasser, S., Zheng, S., Okoro, J., & Wang, L. (2021). Association between per and polyfluoroalkyl substances and markers of P- ISSN 2695-2165 inflammation and oxidative stress. Environmental Research, 196, 110361. https://doi.org/10.1016/j.envres.2020.110361 Oyenuga, V. O., Mosler, G., Addo-Yobo, E., Adeyeye, O. O., Arhin, B., Fortune, F., Griffiths, C. J., Kasekete, M., Mkutumula, E., Reratilwe Mphahlele, Mujuru, H. A., Muyemayema, S., Nantanda, R., Nkhalamba, L. M., Ojo, O. T., Owusu, S. K., Ismail Ticklay, Ubuane, P. O., Yakubu, R. C., & Zurba, L. (2024). Asthma symptoms, severity, and control with and without a clinical diagnosis of asthma in early adolescence in sub-Saharan Africa: a multi-country, school-based, cross-sectional study. The Lancet Child & Adolescent Health. https://doi.org/10.1016/s2352-4642(24)00232-3 Papi, A., Blasi, F., Canonica, G. W., Morandi, L., Richeldi, L., & Rossi, A. (2020). Treatment strategies for asthma: reshaping the concept of asthma management. Allergy, Asthma & Clinical Immunology, 16(1), 75. https://doi.org/10.1186/s13223-020-00472-8 Pham, D. L., Le, K.-M., Truong, D., Le, H. H. T. C., & Trinh, T. (2023). Environmental allergen reduction in asthma management: an overview. Frontiers in Allergy, 4. https://doi.org/10.3389/falgy.2023.1229238 Price, D. B., Trudo, F., Voorham, J., Xu, X., Kerkhof, M., Ling Zhi Jie, J., & Tran, T. N. (2018). Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study. Journal of Asthma and Allergy, 11, 193–204. https://doi.org/10.2147/JAA.S176026 Ramu, S. A., Panduranga, A., & Akarsh, S. (2018). A Study to Assess the Psychosocial Problems and Quality of Life of Parents with Asthmatic Children in Opd’s of Ramaiah Hospitals, Bengaluru. Open Journal of Pediatrics, 08(01), 50–57. https://doi.org/10.4236/ojped.2018.81007 Rappazzo, K., Coffman, E., & Hines, E. (2017). Exposure to Perfluorinated Alkyl Substances and Health Outcomes in Children: A Systematic Review of the Epidemiologic Literature. International Journal of Environmental Research and Public Health, 14(7), 691. Rosenstock, I. M. (1974). Historical Origins of the Health Belief Model. Health Education Monographs, 2(4), 328–335. https://doi.org/10.1177/109019817400200403 Ross, K. R., Gupta, R., DeBoer, M. D., Zein, J., Phillips, B. R., Mauger, D. T., Li, C., Myers, R. E., Phipatanakul, W., Fitzpatrick, A. M., Ly, N. P., Bacharier, L. B., Jackson, D. J., Celedón, J. C., Larkin, A., Israel, E., Levy, B., Fahy, J. V., Castro, M., & Bleecker, E. R. (2020). Severe asthma during childhood and adolescence: A longitudinal study. Journal of Allergy and Clinical Immunology, 145(1), 140-146.e9. https://doi.org/10.1016/j.jaci.2019.09.030 Simoneau, T., & Gaffin, J. M. (2023). Socioeconomic determinants of asthma health. Current Opinion in Pediatrics, 35(3), 337–343. https://doi.org/10.1097/mop.0000000000001235 Stein, S. W., & Thiel, C. G. (2017). The History of Therapeutic Aerosols: A Chronological Review. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 30(1), 20–41. https://doi.org/10.1089/jamp.2016.1297 Suzuki, T., Hidaka, T., Kumagai, Y., & Yamamoto, M. (2020). Environmental pollutants and the immune response. Nature Immunology, 21(12), 1486–1495. https://doi.org/10.1038/s41590-020-0802-6 Thomsen, S. F. (2015). Genetics of asthma: an introduction for the clinician. European Clinical Respiratory Journal, 2(1), 24643. https://doi.org/10.3402/ecrj.v2.24643 Triasih, R., Setyowireni, D., Nurani, N., & Setyati, A. (2023). Prevalence, Management, and Risk Factors of Asthma Among School-Age Children in Yogyakarta, Indonesia. Journal P- ISSN 2695-2165 of Asthma and Allergy, Volume 16, 23–32. https://doi.org/10.2147/jaa.s392733 Tshegofatso Mabelane, Refiloe Masekela, Collet Dandara, & Sabelo Hadebe. (2023). Immunogenetics and pharmacogenetics of allergic asthma in Africa. Frontiers in Allergy, 4. Wenzel, S. E., Fahy, J. V., Irvin, C., Peters, S. P., Spector, S., Szefler, S. J., Casale, T. B., Cloutier, M. M., Elias, J. A., Liu, M. C., & Taggert, V. (2000). Proceedings of the ATS workshop on refractory asthma: Current understanding, recommendations, and unanswered questions. American Journal of Respiratory and Critical Care Medicine, 162(6), 2341-2351. https://doi.org/10.1164/ajrccm.162.6.ats9-00 Willis-Owen, S. A. G., Cookson, W. O. C., & Moffatt, M. F. (2018). The Genetics and Genomics of Asthma. Annual Review of Genomics and Human Genetics, 19(1), 223–246. https://doi.org/10.1146/annurev-genom-083117-021651 Withers, A. Li., & Green, R. (2019). Transition for Adolescents and Young Adults With Asthma. Frontiers in Pediatrics, 7(301). https://doi.org/10.3389/fped.2019.00301 World Health Organization. (2021). Adolescent Health. Who.int; World Health Organization: WHO. https://www.who.int/southeastasia/health-topics/adolescent-health World Health Organization. (2024). Asthma. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/asthma Zhou, W., & Tang, J. (2025). Prevalence and risk factors for childhood asthma: a systematic review and meta-analysis. BMC Pediatrics, 25(1). https://doi.org/10.1186/s12887-025- 05409-x