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Weight Gains in Ampicillin-Resistant Escherichia Coli-Infected Chicks Treated with Ampicillin Stabilized with Medicinal Synthetic Aluminum-Magnesium Silicate (MSAMS®) and Supported by Antioxidant Supplementation

Aniefiok Aniekan Okokon, Maduike Chiehiura Ezeibe and Mary Ekundayo Sanda

Abstract

Antimicrobial resistance in poultry, particularly ampicillin-resistant Escherichia coli , threatens animal health and production efficiency by impairing weight gain and increasing mortality. This study assessed the therapeutic potential of medicinal synthetic aluminum-magnesium silicate -stabilized ampicillin, with and without vitamin C supplementation, in restoring productivity in infected chicks. Eighty chicks were orally challenged with an ampicillin-resistant E. coli strain and randomly assigned to four groups: full-dose ampicillin, reduced-dose MSAMS-stabilized ampicillin, reduced-dose MSAMS- stabilized ampicillin plus vitamin C, and untreated controls. The MSAMS–ampicillin plus vitamin C group achieved the highest post-recovery weight gain (+76.83 g), followed by the MSAMS–ampicillin group (+8.30 g), whereas the ampicillin-only and control groups experienced weight losses (–19.10 g and –55.73 g, respectively). These results suggest that stabilizing ampicillin with MSAMS at a reduced dose, supported by antioxidant supplementation, improves therapeutic efficacy, enhances recovery, and restores weight gain in resistant infections. We recommend the combined use of nano-stabilizers and immune- supportive antioxidants as a sustainable strategy to optimize antimicrobial therapy, and improve productivity in poultry production systems.

Keywords

Antimicrobial resistance; Escherichia coli; Ampicillin; Nano-stabilizing agents; Aluminum-magnesium silicate; Antioxidant supplementation; Weight gain; Poultry

References

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