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The Review of Hybrid Machine Learning Models as a Promising Approach for Disease Diagnosis

Mgbeafulike Ike J, Nwokedi Chidiogo C, Adigwe, A I

Abstract

The use of hybrid machine learning models has gained significant attention in recent years due to the potential it holds in diagnosis. This is especially valuable in the healthcare industry, where timely and accurate disease detection can greatly impact treatment and outcomes for patients. Hybrid models combine the strengths of different machine learning algorithms to overcome the limitations of individual methods allowing for more accurate and efficient disease detection. The versatility of hybrid models allows for the integration of various types of data, such as clinical, genetic, and imaging data. This enables a more comprehensive analysis of disease patterns and leads to more accurate and timely detection. In recent studies, hybrid models have been successfully applied in the detection of various diseases, including cancer, cardiovascular diseases, and infectious diseases. The potential of hybrid machine learning models in disease detection is undeniable. With their ability to handle large and diverse datasets, provide accurate predictions, and adapt to new data, these models have shown promising results and have the potential to greatly impact the field of medicine. Despite the promising results, there are still challenges that need to be addressed in the development and implementation of hybrid machine learning models for disease detection. These include complexity in modal integration, increase in computational cost and complex pre-processing pipeline. In conclusion, hybrid machine learning models have the potential to revolutionize disease detection and significantly improve patient outcomes. With continuous advancements in technology and increasing availability of diverse datasets, these models have the potential to revolutionize the way we detect and diagnose diseases in the future.

Keywords

Machine learning (ML)Hybrid ModelDetectiondiagnosisdataset

References

Ahsan, M. M., Luna, S. A. & Siddique, Z. (2022). Machine-learning-based disease diagnosis: A comprehensive review. Healthcare, 10(3), https://doi.org/10.3390/healthcare10030541 Ain, S. (2023). What is association rule learning? https://medium.com/@ainsupriyofficial/what-is-association-rule-learning- a6ef399fdc01 Akano, T. T., & James, C. C. (2022). An assessment of ensemble learning approaches and single-based machine learning algorithms for the characterization of undersaturated oil viscosity. Beni-Suef University Journal of Basic and Applied Sciences, 11, 1–18. https://doi.org/10.1186/s43088-022-00327-8 Amanatullah, (2023). Perceptron in machine learning. https://medium.com/@amanatulla1606/the-limitations-of-single-layer-perceptron-in- machine-learning-debf0fe959f8 Alnuaimi, A. F. A., & Albaldaawi, T. H. K. (2024). An overview of machine learning classification techniques. BIO Web of Conferences, 97, https://doi.org/10.1051/bioconf/20249700133 Ardila, D., Kiraly, A. P., Bharadwaj, S., Choi, B., Reicher, J. J., Peng, L., Tse, D., Etemadi, M., Ye, W., Corrado, G., Naidich, D. P. & Shetty, S. (2019). End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography. Nature Medicine, 25, 954–961. https://doi.org/10.1038/s41591-019-0447- x Bergmann, D. (2025). What is semi-supervised learning?https://www.ibm.com/think/topics/semi-supervised-learning Chaturvedi, A., & Pathak, N. (2024). Introduction and types of machine learning. In Artificial intelligence and their applications, 151-186. https://iipseries.org/assets/docupload/rsl202467DF4A0306B437B.pdf Deb, C., Zhang, F., Yang, J., Lee, S. E. & Shah, K. W. (2017). A review on time series forecasting techniques for building energy consumption. Renewable and Sustainable Energy Reviews, 74, 902–924. https://doi.org/10.1016/j.rser.2017.02.085 Gavrilova, Y. (2024). What is semi-supervised learning? https://serokell.io/blog/semi-supervised-learning-basics Jain, A. (2024). Different types of ensemble techniques — Bagging, Boosting, Stacking, Voting, Blending. https://medium.com/@abhishekjainindore24/different- types-of- ensemble-techniques-bagging-boosting-stacking-voting-blending- b04355a03c93 Kanade, V. (2022a). What is reinforcement learning? https://www.spiceworks.com/tech/artificial-intelligence/articles/what-is- reinforcement-learning/ Kanade, V. (2022b). What is dimensionality reduction? https://www.spiceworks.com/tech/artificial-intelligence/articles/what-is- dimensionality-reduction/ Kalirane, M. (2025). Bagging, Boosting, and Stacking: Ensemble learning in ML models. https://www.analyticsvidhya.com/blog/2023/01/ensemble-learning-methods-bagging- boosting-and-stacking/#h-what-is-stacking Lovett, L. (2020). Study: Google AI tech shows promise in detecting breast cancer. https://www.mobihealthnews.com/news/study-googles-ai-tech-shows-promise- detecting-breast-cancer Lokesh, S. & Ravinder, K. (2022). An Ensemble of Random Forest Gradient Boosting Machine and Deep Learning Methods for Stock Price Prediction. Journal of Information Technology Research, 15 (1), 1-19. Maha, R., Ghadha, I. F. & Hanan, A. (2018). Neurological disorders: Causes and treatments strategies. International Journal of Public Mental Health and Neurosciences, 5(1), 32– Mohammed, A. & Kora, R. (2023). A comprehensive review on ensemble deep learning: Opportunities and challenges. Journal of King Saud University - Computer and Information Sciences, 35(2), 757–774. Oluwafemi, G., Faith, R. & Badmus, J. (2024). Hybrid models combining machine learning and traditional epidemiological models. International Journal of Circumpolar Health. https://www.researchgate.net/publication/387723315_Hybrid_Models_Combining_M achine_Learning_and_Traditional_Epidemiological_Models Pandey, A. K. (2023). Regression algorithms. https://arunp77.medium.com/regression- algorithms-29f112797724 Richens, J. G., Lee, C. M. & Johri, S. (2020). Improving the accuracy of medical diagnosis with causal machine learning. Nature Communications, 11, https://doi.org/10.1038/s41467-020-17419-7 Sambasivam, G., Prabu Kanna, G., Chauhan, M. S., Raja, P. & Kumar, Y. (2025). A hybrid deep learning model approach for automated detection and classification of cassava leaf diseases. Scientific Reports, 15, 7009. https://doi.org/10.1038/s41598-025-90646-4 Sanjeev, G., Shimna, M. K., Apoorva, J., Ambrish, K. S., Shital, G. & Karuna, N. P. (2025). Hybrid machine learning for disease diagnosis: A review of case studies and performance evaluation using multi-source data. Journal of Information Systems Engineering and Management, 10(36s), 604–612. https://doi.org/10.52783/jisem.v10i36s.6537 Sara, B. V. J., Jaiswal, A. S. & Gokulakrishnan, A. (2024). Hybrid machine learning models: Trends in combining neural approaches. Musik in Bayern, 89(12), 147–155. Sathya, D., Sudha, V., & Jagadeesan, D. (2022). Application of machine learning techniques in healthcare. In I. Management Association (Ed.), Research anthology on machine learning techniques, methods, and applications, 1294–1310. https://doi.org/10.4018/978-1-6684-6291-1.ch067 Shivahare, B., Singh, J., Ravi, V., Chandan, R., Alahmadi, T., Singh, P. & Diwakar, M. (2024). Delving into machine learning influence on disease diagnosis and prediction. Open Public Health Journal, 17, e18749445297804. https://doi.org/10.2174/0118749445297804240401061128 Shukla, P. (2023). How blending technique improves machine learning model’s performance. https://dataaspirant.com/blending-technique-machine-learning/ Siadati, S. (2018). What is unsupervised learning? Conference presentation. Khaje Nasir Toosi University of Technology. https://doi.org/10.13140/RG.2.2.33325.10720 Singh, H. (2025). What is reinforcement learning and how does it work (Updated 2025). https://www.analyticsvidhya.com/blog/2021/02/introduction-to-reinforcement- learning-for-beginners/ Swanson, K., Wu, E., Zhang, A., Alizadeh, A. & Zou, J. (2023). From patterns to patients: Advances in clinical machine learning for cancer diagnosis, prognosis, and treatment. Cell, 186, 1772–1791. Tomar, N. (2023). Types of machine learning. https://idiotdeveloper.com/types-of-machine- learning/ Verma, S., Singh, P. K., Kaur, G., Vashistha, A., & Pansari, S. (2025). Non-invasive kidney stone prediction using machine learning: An extensive review. Biomedical Pharmacology Journal, 18(March Special Edition). World Heart Federation. (2025). Diabetes. https://world-heart-federation.org/what-we- do/diabetes/ Yuvaraj, B., Thumilvannan, S., Josephine, D. C. J., & Leo, S. A. (2023). A hybrid machine learning approach for early detection of paddy blight disease. ICTACT Journal on Soft Computing, 13(4), July 2023. Zhang, B., Shi, H., & Wang, H. (2023). Machine learning and AI in cancer prognosis, prediction, and treatment selection: A critical approach. Journal of Multidisciplinary Healthcare, 16, 1779–1791. https://doi.org/10.2147/JMDH.S410301

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