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Global Prevalence of Metabolic Disorders, Associated Factors and Management

Oyewole Samuel Aanuoluwa & Professor James Ebun Atolagbe

Abstract

Metabolic disorders, including diabetes, obesity, metabolic syndrome, and dyslipidemia, have become significant global health concerns due to their rising prevalence and association with increased morbidity and mortality. These disorders contribute to the growing burden of non- communicable diseases (NCDs), which are now among the leading causes of death worldwide. The increasing incidence of metabolic disorders is driven by a complex interplay of genetic, behavioral, environmental, and socioeconomic factors. Rapid urbanization, sedentary lifestyles, unhealthy dietary patterns, and socioeconomic disparities have exacerbated the problem, particularly in low- and middle-income countries where healthcare access is limited. This study was conducted through an extensive literature review, synthesizing data from peer- reviewed journals, global health reports, and epidemiological studies to assess the prevalence, associated risk factors, and management strategies for metabolic disorders across different populations. The findings indicate that while genetic susceptibility plays a role, lifestyle and environmental factors remain the most significant contributors to metabolic disorders. Industrialization and urban living have led to an increased intake of processed foods high in refined sugars and unhealthy fats, contributing to obesity and insulin resistance. Additionally, reduced physical activity and prolonged sedentary behavior have further heightened the risk of metabolic dysfunction. Effective management of metabolic disorders requires a comprehensive and multidisciplinary approach that includes early screening, lifestyle interventions, pharmacological treatments, and public health policies aimed at prevention. Innovations in medical technology, such as digital health tools, telemedicine, and personalized medicine, have enhanced the early diagnosis and treatment of these conditions. However, challenges persist in many regions, par

Keywords

PrevalenceMetabolic DisordersAssociated FactorsManagement

References

Adepoju, O. T., & Adejoh, S. O. (2021). Effect of whole grains on glycemic control among Nigerian adults with type 2 diabetes. Journal of Nutrition and Metabolism, 18(3), 45-56. Adebayo, K. O., et al. (2020). Legumes and their impact on metabolic health: A Nigerian perspective. African Journal of Food Science, 12(4), 112-124. Ajani, E. O., et al. (2018). Dietary sources of omega-3 fatty acids and their role in cardiovascular health. Nigerian Journal of Cardiology, 6(2), 78-89. Chukwuonye, I. I., et al. (2018). The burden of metabolic disorders in Nigeria: A systematic review. BMC Public Health, 18(1), 499. Ogunleye, A. A., et al. (2019). Sugar-sweetened beverage consumption and obesity risk in Nigerian adults. Journal of Public Health Research, 7(3), 189-202. Olowe, F. A., et al. (2021). Effect of sodium-rich diets on hypertension prevalence in Nigeria. West African Journal of Medicine, 38(1), 12-19. Adebiyi, A. O., et al. (2020). Adapting the DASH diet to Nigerian dietary patterns for hypertension management. Journal of Clinical Nutrition, 15(2), 205-216. Okafor, C. N., et al. (2019). Mediterranean diet principles and their application to Nigerian cuisine. African Journal of Nutritional Studies, 14(4), 250-265. Ogunbode, A. M., et al. (2022). Government policies and their impact on nutritional health in Nigeria. Nigerian Journal of Policy Studies, 10(1), 88-104. Adedoyin, R. A., Afolabi, A., Adegoke, O. O., Akintomide, A. O., & Awotidebe, T. O. (2013). Relationship between socioeconomic status and metabolic syndrome among Nigerian adults. Diabetes & Metabolic Syndrome Clinical Research & Reviews, 7(2), 91–94. https://doi.org/10.1016/j.dsx.2013.02.014 Adegoke, O. A., Adedoyin, R. A., Balogun, M. O., Adebayo, R. A., Bisiriyu, L. A., & Salawu, A. A. (2009). Prevalence of metabolic syndrome in a rural community in Nigeria. Metabolic Syndrome and Related Disorders, 8(1), 59–62. https://doi.org/10.1089/met.2009.0037 Adejumo, E., Ogundahunsi, O., Adejumo, O., Sotunsa, J., & Jagun, O. (2017). Prevalence of metabolic syndrome in a rural and urban community in South-West Nigeria using three different definitions. International Journal of TROPICAL DISEASE & Health, 24(2), 1– https://doi.org/10.9734/ijtdh/2017/33993 Akhlaghi, M. (2019). Dietary Approaches to Stop Hypertension (DASH): potential mechanisms of action against risk factors of the metabolic syndrome. Nutrition Research Reviews, 33(1), 1–18. https://doi.org/10.1017/s0954422419000155 Akkol, E. K., & Aschner, M. (2022). An overview on metabolic disorders and current therapy. In Elsevier eBooks (pp. 3–33). https://doi.org/10.1016/b978-0-12-824356-5.00004-7 Alamnia, T. T., Sargent, G. M., & Kelly, M. (2023). Dietary patterns and associations with metabolic risk factors for non-communicable disease. Scientific Reports, 13(1). https://doi.org/10.1038/s41598-023-47548-0 Allen, L., Williams, J., Townsend, N., Mikkelsen, B., Roberts, N., Foster, C., & Wickramasinghe, K. (2017). Socioeconomic status and non-communicable disease behavioural risk factors in low-income and lower-middle-income countries: a systematic review. The Lancet Global Health, 5(3), e277–e289. https://doi.org/10.1016/s2214-109x(17)30058-x Al-Qawasmeh, R. H., & Tayyem, R. F. (2018). Dietary and Lifestyle Risk Factors and Metabolic Syndrome: Literature review. Current Research in Nutrition and Food Science Journal, 6(3), 594–608. https://doi.org/10.12944/crnfsj.6.3.03 Amadi, C. E., Mbakwem, A. C., Duro, D. C., Udenze, I. C., Akinsola, C. M., Ajuluchukwu, J. N., & Oke, D. a. W. (2022). Prevalence, patterns and predictors of metabolic abnormalities in Nigerian hypertensives with hypertriglyceridemic waist phenotype: A cross sectional study. PLOS Global Public Health, 2(12), e0001203. https://doi.org/10.1371/journal.pgph.0001203 Barnett, A., Martino, E., Knibbs, L. D., Shaw, J. E., Dunstan, D. W., Magliano, D. J., Donaire- Gonzalez, D., & Cerin, E. (2022). The neighbourhood environment and profiles of the metabolic syndrome. Environmental Health, 21(1). https://doi.org/10.1186/s12940-022- 00894-4 Bhurosy, T., & Jeewon, R. (2014). Overweight and Obesity Epidemic in Developing Countries: A Problem with Diet, Physical Activity, or Socioeconomic Status? The Scientific World JOURNAL, 2014, 1–7. https://doi.org/10.1155/2014/964236 Blanquet, M., Debost-Legrand, A., Gerbaud, L., De La Celle, C., Brigand, A., Mioche, L., Sass, C., Hazart, J., & Aw, A. (2015). Metabolic syndrome and social deprivation: results of a French observational multicentre survey. Family Practice, 33(1), 17–22. https://doi.org/10.1093/fampra/cmv086 Bonnet, F., & Scheen, A. (2016). Understanding and overcoming metformin gastrointestinal intolerance. Diabetes Obesity and Metabolism, 19(4), 473–481. https://doi.org/10.1111/dom.12854 Cao, H. (2014). Adipocytokines in obesity and metabolic disease. Journal of Endocrinology, 220(2), T47–T59. https://doi.org/10.1530/joe-13-0339 Chew, N. W. S., Ng, C. H., Jun, D., Tan, H., Mantzoros, C. S., & Sanyal, A. (2023). Clinical and Translational Report The global burden of metabolic disease?: Data from 2000 to 2019 ll Clinical and Translational Report The global burden of metabolic disease?: Data from 2000 to 2019. Cell Metabolism, 35(3), 414-428.e3. https://doi.org/10.1016/j.cmet.2023.02.003 Chung, J., Choi, H., Jung, J., & Kong, M. G. (2021). Association between Socioeconomic Status and Metabolic Syndrome in Korean Adults: Data from the Korean National Health and Nutrition Examination Survey. CardioMetabolic Syndrome Journal, 1(2), 168. https://doi.org/10.51789/cmsj.2021.1.e16 Clemente-Suárez, V. J., Martín-Rodríguez, A., Redondo-Flórez, L., López-Mora, C., Yáñez- Sepúlveda, R., & Tornero-Aguilera, J. F. (2023). New insights and potential therapeutic interventions in metabolic diseases. International Journal of Molecular Sciences, 24(13), https://doi.org/10.3390/ijms241310672 Cleven, L., Krell-Roesch, J., Schmidt, S. C. E., Dziuba, A., Bös, K., Jekauc, D., & Woll, A. (2022). Longitudinal association between physical activity and the risk of incident metabolic syndrome in middle-aged adults in Germany. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-24052-5 Darbre, P. (2018). Overview of air pollution and endocrine disorders. International Journal of General Medicine, Volume 11, 191–207. https://doi.org/10.2147/ijgm.s102230 Davies, K. a. B., Sprung, V. S., Norman, J. A., Thompson, A., Mitchell, K. L., Halford, J. C. G., Harrold, J. A., Wilding, J. P. H., Kemp, G. J., & Cuthbertson, D. J. (2018). Short-term decreased physical activity with increased sedentary behaviour causes metabolic derangements and altered body composition: effects in individuals with and without a first-degree relative with type 2 diabetes. Diabetologia, 61(6), 1282–1294. https://doi.org/10.1007/s00125-018-4603-5 Franquesa, M., Pujol-Busquets, G., García-Fernández, E., Rico, L., Shamirian-Pulido, L., Aguilar- Martínez, A., Medina, F. X., Serra-Majem, L., & Bach-Faig, A. (2019). Mediterranean Diet and Cardiodiabesity: A Systematic Review through Evidence-Based Answers to Key Clinical Questions. Nutrients, 11(3), 655. https://doi.org/10.3390/nu11030655 Gallwitz, B. (2016). Novel therapeutic approaches in diabetes. Endocrine Development, 43–56. https://doi.org/10.1159/000439372 Garg, C., Khan, H., Kaur, A., Singh, T. G., Sharma, V. K., & Singh, S. K. (2022). Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment. Pharmacological Research, 179, https://doi.org/10.1016/j.phrs.2022.106194 Goodchild, M., Nargis, N., & D’Espaignet, E. T. (2017). Global economic cost of smoking- attributable diseases. Tobacco Control, 27(1), 58–64. https://doi.org/10.1

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