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Virulence Factors and Pathogenic Mechanisms of Hepatitis Viruses Versus Host Innate Immunity

Asif BB, Imrana AM, Susuti E, Mary CM, Mohammed YA, Fatima AA

Abstract

The liver fulfils key functions in metabolism for proteins, carbohydrates, and lipids and for elimination of toxic waste products via bile. However, certain conditions can cause the inflammation of the liver such as use of alcohol, some certain medical conditions, toxins and medications, inflammation of the liver is most often caused by a virus. Meanwhile, viral hepatitis is caused by any of the five hepatotropic viruses, i.e hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). These viruses belongs to different families which include; Hepatitis A is caused by infection with hepatitis A virus (HAV), a non-enveloped RNA virus that is classified as a picornavirus and was first discovered in the 1973, Hepatitis B virus (HBV), is a member of the family Hepadnaviridae, it was discover in the 1960s, hepatitis C is an infectious disease caused by the hepatitis C virus (HCV), which is an RNA virus of the family Flaviviridae, and was discovered in the year 1989, The smallest virus known to infect humans is hepatitis delta virus (HDV), Hepatitis delta virus was discovered by Rizzetto in 1977 and was initially described as new antigen detectable in patients with HBV-associated chronic liver disease. HEV is a single- stranded, nonenveloped RNA virus and is the only virus within the family Hepeviridae, it was first recognised in the year 1980. These viruses have different virulence factors which enable them to replicate and disseminate within a host in part by subverting or eluding host defences. Furthermore, just as they have different virulence factors, they vary greatly in terms of pathogenic mechanism as well as host immunity evasion mechanisms. The immune systems interact with these viruses upon entry into the cells. The innate immune system serves as the initial immune defence against foreign and dangerous materials such as viruses. In conclusion, all used

Keywords

Hepatitis virusVirulence factorsImmune systemPathogenic mechanism

References

: Abbas, Z. and Afzal, R. (2013). Life cycle and pathogenesis of hepatitis D virus?: A review Life cycle and pathogenesis of hepatitis D virus: A review. World Journal of Hepatology, 5(12):666–675. Akaiwa, M., Yae, Y., Sugimoto, R., Suzuki, S.O., Iwaki, T., Izuhara, K. and Hamasaki, N. (1999). Hakata antigen, a new member of the ficolins/Opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and ile. Journal of Histochemistry and Cytochemistry,6:777-786. Attia, F., Megahed, K. and Zhou, X. (2020). The Interactions Between HBV and the Innate Immunity of Hepatocytes. Viruses, 12(285):1–14. Banchereau, J., Briere, F. Caux, C., Davoust, J., Lebecque, S. and Liu, Y. (2000). Immunology of dendritic cells. Annual Review Immunology, 18:767-811. Barrionuevo, P., Beigier-Bompadre, M., Ilarregui, J.M., Toscano, M.A., Bianco, G.A., Isturiz, M.A. and Rabinovich, G.A. (2007). A novel function for galectin-1 at the crosssoad of innate and adaptive immunity. Journal of Hepatology, 4:45-6. Bertoletti, A. and Gehring, A. J. (2006). The immune response during hepatitis B virus infection. Journal of General Virology, 87(20):1439–1449. Buti, M. and Razavi, H. (2017). Hepatitis C virus infection. Nature Reviews Disease Primers, 3(17006):1–20. Bayry, J., Lacroix-Desmazes, S., Kazatchkine, M.D., Hermine, O., Tough, D.F. and Kaveri, S.V. (2005). Modulation of dendritic cells maturation and function by B lymphocyte. Journal of Immunology,175:15-20. CDC. (2020). Hepatitis A. U.S. Department of Health and Human Services. Www.cdc.gov/hepatitis. 21-24. CDC. (2012). Hepatitis C virus ( HCV ). In www.cdc.gov/ncidod/diseases/hepatitis/c. Contact,302:744–1050. Www.cdc.gov/ncidod/diseases/hepatitis/c.Contact. Cerwenka, A., and Lanier, L.L. (2001). Natural killer cells, viruses and cancer. Natures Review Immunolog,. 1:41-9. Cross, A.S. (2009). What is a virulence factor? Critical Care, 12(6). Https://doi.org/10.1186/cc7127 Cruvinel, W.D., Melo, D., Mesquita, J., Julio, A., Pereira A., Tânia, T. and Takao, C. (2010). “Fundamentals of Innate Immunity with.” Brasilian Journal of Rheumatol 55 (11):1– Dranoff, D. (2004). Lecture 1 - Innate Immune System. Natures Reviews Cancer, 4:11–22. Faure, S., Lucifora, J., and Durantel, D. (2017). Interplay between the Hepatitis B Virus and Innate Immunity: From an Understanding to the Development of Therapeutic Concepts. Viruses, 9(95):1–21. Fayer, R., Orlandi, P., and Perdue, M. L. (2009). Virulence factor activity relationships for hepatitis E and Cryptosporidium. Journal of Water and Health, 7(1): 55–63. Fitzgerald-Bocarsly, p., and Feng, D. (2007). The role of type I interferon production by dendritic cells in host defense. Biochemistry,89:843-855. Gholamreza, R., Shahryar, S., Abbasali, K., Hamidreza, J., Abdolvahab, M., Khodaberdi, K., Danyal, R. and Nafiseh, A. (2007). Seroprevalence of hepatitis B virus and its co- infection population. Indian Journal of Medical Sciences, 263(264):153–155. Guidotti, L. G. and Chisari, F. V. (2006). Immunobiology and Pathogenesis of Viral Hepatitis. Annual Review of Pathology Mechanisms of Disease, 1:23–61. IOCI. (2008). Hepatitis A. State of lllinois, Department of Public Health.22-24. Iwasaki A. andMedzhitove, R. (2010). Regulation of adaptive immunity by the innate immune system,Science 327:291-295. Khudyakov, Y. (2012). Review Molecular surveillance of hepatitis C. Antiviral Therapy, 17, 1465–1470. Khuroo, M. S., Kamili, S. and Khuroo, M. (2004). Hepatitis E. In R. H. W. B. Al Knawy, M.L. Shiffman (Ed.), Hepatology (Issue November 2014:1–13. Article in press. Https://doi.org/10.13140/2.1.3395.5525 Knolle, P. A. and Thimme, R. (2014). Hepatic Immune Regulation and Its Involvement in Viral Hepatitis Infection. Gastroenterology, 146(5):1193–1207. s Kumar, V., Das, S. and Jameel, S. (2010). The biology and pathogenesis of hepatitis viruses. Current science, 9(3):1–15. Leikina, E., Delanoe-Ayari, H., Meleikov, K., Chen, A., Waring, A.J., Wang, W., Xie, Y., Loo, J.A. and Lehrer, R.I. (2005). Carbohydrate-binding molecules inhibit viral fusion and entry by cross-linking membrane glycoproteins. Natural immunology, 6:995-1001. Leit, J. H. (2020). Microbial Virulence Factors. Molecular Science, 21:(5320). Lemon, S. M., Ott, J. J., Damme, P. Van, and Shouval, D. (2018). Type A viral hepatitis?: A summary and update on the molecular virology, epidemiology, pathogenesis and prevention. Journal of Hepatology, 68(1):167–184. Manns, M.P., and WH, S.P. (2012). Pathogenesis and Treatment of Hepatitis E Virus Infection. Gastroenterology, 142(6): 1388–1397. Margolis, H. S., Alter, M. J., and Hadler, S. C. (2016). Viral Hepatitis. viral hepatitis, 9(2–57). Mark, A. (2018). Liver Disease.Liver cancer, 6:1–21). Metcalf, D.D. (2008). Mast cells and mastocytosis. Blood. 112:946-56. Mizukoshi, E. and Rehermann, B. (2014). Immune responses and immunity in hepatitis C virus infection. Journal of Gastroenterology, 2001(36):799–808. Nainan, O. V., Xia, G., Vaughan, G. and Margolis, H. S. (2006). Diagnosis of Hepatitis A Virus Infection?: A Molecular Approach. Clinical Microbiology Review, 19(1): 63–79. NIH. (2013). Viral Hepatitis C: Introduction. In The NIH clinical trial website, (1–8). The NIH clinical trial website Rehermann, B. and Nascimbeni, M. (2005). Immunology of hepatitis b virus and hepatitis c virus infection.Nature revies/Immunology, 5(215):1–16. Sarowska, J., Koloch, B. F., Kmiecik, A. J., Madrzak, M. F., Ksiazczyk, M., Ploskonska, G.B. and Krol, I. (2019). Virulence factors, prevalence and potential transmission of extraintestinal pathogenic Escherichia coli isolated from different sources: recent reports. Gut Pathogens, 11(10):1–16. Stockdale, A. J., Kreuels, B., Henrion, M.R., De, C., Hutin, Y. and Geretti, A. M. (2020). The global prevalence of hepatitis D virus infection?: Systematic review and meta-analysis The global prevalence of hepatitis D virus infection. Journal of Hepatology, 73(3), 523– Suslov, A., Boldanova, T., Wang, X., Wieland, S. and Heim, M.H. (2018). Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver. Gastroenterology, 154(6): 1778–1790. Turvey, S. E. and Broide, D.H. (2010). Innate immunity. Journal of Allergy and Clinical Immunology, 125(2):24–32. Vasickova, P., Psikal, I., Kralik, P., Widen, F., Hubalek, Z., and Pavlik, I. (2007). Hepatitis E virus, Veterinarni Medicina, 52(9):365–384. Wang, C., Tschen, S., Heinricy, U., Weber, M. and Flehmig, B. (1996). Immune Response to Hepatitis A Virus Capsid Proteins after Infection. Journal of Clinical Microbiology, 34(3):07–713. Wedemeyer, H. and Manns, M.P. (2010). Epidemiology, pathogenesis and management of hepatitis D?: update and challenges ahead. Nature Reviews Gastroenterology and Hepatology, 7(1):31–40. WHO.(2002). Hepatitis B, Http://www.who.int/emc 23-25. WHO. (2012). Prevention and Control of Viral Hepatitis Infection?: Framework for Global Action, 7:1–28. Www.who.int/topics/hepatitis. Wilson, D.E., Melo, C., Danilo, M.J.,Julio, P.A., Tania, T.K., Alexender, W.S., Neusa, P.S. and Luis, E.A. (2010). Fundamental of innate immunity with emphasis on molecular and cellular mechanisms of inflamatory response Bras. Journal of Rheumatology, 50:434-6.