Epigenetic Mechanisms in Metal Carcinogenesis (Article Review)
Abstract
Although carcinogenic metals have been demonstrated to disrupt a number of biological processes, the precise mechanism by which they cause cancer is uncertain. Research over the past decade or so suggests that epigenetic mechanisms may play a role in metal-induced carcinogenesis. This paper compiles evidence that exposure to carcinogenic metals, including nickel, arsenic, chromium, and cadmium, can change worldwide and gene-specific histone tail posttranslational modification marks and DNA methylation levels. Additionally, we would like to stress the significance of comprehending that both genetic and epigenetic mechanisms can regulate gene expression, and that both of these need to be taken into account when researching the mechanisms behind the toxicity and cell-transforming potential of carcinogenic metals and other toxicants, as well as aberrant changes in gene expression that take place during disease states like cancer.
Keywords
DNACancermetalActiveDNA MethylationGlobal Hypomethylation Promoter HypermethylationHistone Modifications
References
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