Synthesis, Characterization and Antimicrobial Studies of Co(II), Fe(II) and Ni(II) Tosylated 4-aminopyridine Complexes

Abstract

The research investigates the synthesis of tosylated 4-aminopyridine complexed with cobalt(II), iron(II), and nickel(II) and its used as antibacterial agents. The purity of the ligand and its complexes was determined using melting point and thin-layer chromatography techniques. The chemical properties were assessed by the utilisation of Ultraviolet-Visible Spectroscopy (UV- VIS), Infrared (IR), Molar Conductivity, Electrospray Ionisation Mass Spectrometry (ESI-MS), and Nuclear Magnetic Resonance (NMR) techniques. The free imine nitrogen in the ligands vibrated at a higher frequency than the complexes' coordinated imine. This suggests the transfer of lone pair electrons from the free azomethine nitrogen to the metal ions. A variety of microorganisms was used to determine the antimicrobial potential of both ligand and their complexies. The findings revealed that the ligand had no effect on bacterial or fungal strains, whereas, the complexes were sensitivity on some microbes. The bioactivity of monotosylated 4-aminopyridine was greatly enhanced by its complexes. Among the clinical pathogens, S. cerevisiae is most affected by the iron(II) complex.

Keywords

References