The Influence of Chronic Plantain Meal Consumption on Exploratory, Locomotory and Weight Dynamic in Experimental Mice Model

Abstract

The effect of consuming plantain diet chronically on some Neurobehaviour parameters was investigated in mice that weighted between 20.2kg –27.4kg. A random selection was made for mice categorized into three (3), such that two categories were allowed to consume either reduced (MD) or increased (PD) quantity of plantain meal, while one category had normal mouse feed; all under normal regulated condition of temperature and light/dark hours during the 30 days design of the experiment. Neurobehaviour parameters studied were exploration and locomotion activities alongside weight dynamics. After neurobehaviour studies, animals are euthanized, brain homogenates was analyzed to determine 5-HT quantity. The results obtained indicates differential food consumption rate (p<0.05) for all categories of animals; highest in control, followed by MD and PD category. There was increased (p<0.05) drinking rate for PD mice than control, but did not vary between MD vs. control. The body weight dynamic for the PD mice is increased (p<0.05) than those of MD categories with control. The frequencies at which they crossed lines, climbed wall and rear in air decreased (p<0.05) for MD , PD categories than control. 5-HT concentration was significantly (p<0.001) higher in the PD than MD and control categories. These observations imply an increased weight dynamic in MD and PD categories of mice. They also exhibited greater propensity for drinking water, but decreased exploratory with locomotory tendencies; probably not unconnected with 5-HT

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