INTERNATIONAL JOURNAL OF MEDICAL EVALUATION AND PHYSICAL REPORT (IJMEPR )

E-ISSN 2579-0498
P-ISSN 2695-2181
VOL. 8 NO. 5 2024
DOI: 10.56201/ijmepr.v8.no5.2024.pg83.89


The Effect of Hydro-Methanolic Seed Extract of Azanza garckeana (Goron Tula) on Lipid Profile and Oxidative Stress Markers of Male Wistar Rats

Onyebuchi Obia, Hannah Ezekiel-Hart, Joy O. A Laz-Okenwa, Edith Reuben, Dagbota Dan-Jumbo and Chisom F. Wami-Amadi


Abstract


The prevalence of cardiometabolic conditions has risen globally over the years even in the low- and middle-income countries. The present study was aimed at investigating the effects of hydro- methanolic seed extract of Azanza garckeana on the lipid profile and oxidative stress markers of male wistar rats. A total of 20 wistar rats were separated into four groups of five rats each; including group 1 which served as control. Groups 2, 3, and 4 respectively received a daily dose of 250mg/kg, 500mg/kg, and 1000mg/kg of the extract. The body weight of the animals was taken on day 1 and day 28. The experiment lasted for 28 days, thereafter, the animals were sacrificed and blood samples collected for the determination of lipid profile and oxidative stress markers. The result showed that 1000mg/kg of the extract caused a significant increase in total cholesterol, low-density lipoprotein, and very low-density lipoprotein levels but no significant effect on the triglyceride, and high-density lipoprotein. The percentage of weight gain was significantly reduced compared to control. 250mg/kg and 500mg/kg of the extract did not cause significant changes in the lipid profile parameters. There were also no significant changes in the oxidative stress parameters. This therefore suggests that at higher doses hydro-methanolic seed extract of Azanza garckeana despite causing dyslipidaemia, may have a weight protective effect and would not potentially increase lipid peroxidation in male wistar rats.


keywords:

Azanza garckeana, lipid profile, oxidative stress markers.


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