IIARD International Institute of Academic Research and Development

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH (IJHPR )

E-ISSN 2545-5737
P-ISSN 2695-2165
VOL. 10 NO. 2 2025
DOI: 10.56201/ijhpr.vol.10.no2.2025.pg66.79

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Use of Vegetables to Manage Diabetes in Diabetes Induced Rats

Yepshak, Nanyen B, Saidu, Godiya M and Dapas, Afiniki E

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Abstract

The study identified some lesser-known vegetables in plateau state through a focus group discussion. The extracts of the identified vegetables were used to manage Diabetic induced rats. The lesser known vegetables used were identified at the Botany Department’s herbarium of the University of Jos. The vegetables were P. crispum, B. pilosa, L. taraxicifolia and V. doniana. The leaves were sorted, cleaned and processed into powdered samples; extracts were derived using aqueous extraction. One gram of the powdered leaves was soaked in 100ml distilled water to produce a concentration of 10mg/ml of the acqueos extract used for the experiment. Acute toxicity test LD50 was conducted on the four leaf extracts using six mice per extract. The study adopted survey and experimental methods. A total of 66 adult rats were used for the study. The rats were divided into 11 groups of 6 each for the diabetes study. The rats were induced with a single dose of 150mg/kg body weight of freshly prepared aloxan monohydrade interperetonially, except the first group used for the control. The rats were then divided into 8 groups treated with 500mg/kg body weight and 1000mg/kg body weight of the vegetable extracts. Another group was given 500mg/kg body weight of the standard drug glibenclamide while one group was induced but not treated used as another control. The diabetic study lasted for 13 days. Their blood glucose and lipid profiles were dertermined. Paired sample t-test was used to analyze the baseline and end line data on blood glucose levels and lipid profiles. Statistical analysis revealed that the four aqueous leaf extracts were of good nutrient quality and within the safe level. That all the groups except the first controls (undiabetic untreated) had post-induction elevated fasting blood glucose (above 10mmol/dl), lipid profiles, and lowered high density lipoprotein. When treated with the four aqueous leaf extracts at 500mg/kg and 100mg/kg b

keywords:

Diabetes, Vegetables, Lesser Known, Rats

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