INTERNATIONAL JOURNAL OF MEDICAL EVALUATION AND PHYSICAL REPORT (IJMEPR )

E-ISSN 2579-0498
P-ISSN 2695-2181
VOL. 9 NO. 3 2025
DOI: 10.56201/ijmepr.v9.no3.2025.pg90.114


Investigating the Impact of Antimicrobial Resistance on Global Health and Combating Strategies

Dr Oyedeji Olugbenga James


Abstract


The rising threat of antimicrobial resistance (AMR) has prompted the need for alternative approaches to managing antibiotic use in animal production. This study investigates the impact of restrictive antibiotic use in Sweden’s animal production sector, focusing on its implications for AMR containment. Using a qualitative approach, the research explores the perspectives of key stakeholders, including farmers, veterinarians, and policymakers, on the feasibility and effectiveness of antibiotic restrictions. In-depth interviews and focus group discussions were conducted to assess the strategies adopted, challenges faced, and the perceived benefits and drawbacks of reduced antibiotic usage in animal husbandry. Findings indicate that while restrictive measures have contributed to a reduction in antibiotic use, they also highlight concerns regarding animal health, productivity, and economic viability. Additionally, stakeholders emphasized the need for more robust surveillance systems, education on alternative management practices, and greater cooperation among various sectors to ensure the sustainable success of antibiotic reduction strategies. This study underscores the importance of balancing antibiotic stewardship with the overall well-being of the animal production system to effectively combat AMR.


keywords:

Antimicrobial Resistance (AMR), Antibiotic Stewardship, Animal Production, Sweden, Qualitative Study


References:


Africa CDC. (2022). Africa CDC Framework for AMR Surveillance.
Ahmed, S. K., Hussein, S., Qurbani, K., Ibrahim, R. H., Fareeq, A., Mahmood, K. A., & Mohamed,
M. G. (2024). Antimicrobial resistance: Impacts, challenges, and future prospects. Journal
of
Medicine,
Surgery,
and
Public
Health,
2,
Article
https://doi.org/10.1016/j.glmedi.2024.100081
Ahmed, S. K., Hussein, S., Qurbani, K., Ibrahim, R. H., Fareeq, A., Mahmood, K. A., & Mohamed,
M. G. (2024). Antimicrobial resistance: Impacts, challenges, and future prospects. Journal
of
Medicine,
Surgery,
and
Public
Health,
2,
Article
https://doi.org/10.1016/j.glmedi.2024.100081
Ajekiigbe, V. O., Ogieuhi, I. J., Odeniyi, T. A., Ogunleke, P. O., Olatunde, J. T., Babalola, A. V.,
Omoleke, A. A., Omitade, T. F., Olakanmi, D. E., Akingbola, A., & Anthony, C. S. (2025).
Understanding Nigeria’s antibiotic resistance crisis among neonates and its future
implications. Discover Public Health, 22(28). https://doi.org/10.1186/s12982-025-00422-
y
Alabi, E. D., Rabiu, A. G., & Adesoji, A. T. (2025, June). A review of antimicrobial resistance
challenges in Nigeria: The need for a one health approach. One Health, 20, 101053.
https://doi.org/10.1016/j.onehlt.2025.101053
Alm, R. A., & Gallant, K. (2020). Innovation in antimicrobial resistance: The CARB-X
perspective.
ACS
Infectious
Diseases,
6(6),
1317–1322.
https://doi.org/10.1021/acsinfecdis.0c00026PAHO (2021). Antimicrobial Resistance in
the Americas: Report on Surveillance and Trends.
Baur, D., Gladstone, B. P., Burkert, F., Carrara, E., Foschi, F., Döbele, S., & Tacconelli, E. (2017).
Effect of antibiotic stewardship on the incidence of infection and colonisation with
antibiotic-resistant bacteria and Clostridium difficile infection: A systematic review and
meta-analysis.
The
Lancet
Infectious
Diseases,
17(9),
990-1001.
https://doi.org/10.1016/S1473-3099(17)30325-0
Björkman, I., Röing, M., Lewerin, S. S., Lundborg, C. S., & Eriksen, J. (2021). Animal production
with restrictive use of antibiotics to contain antimicrobial resistance in Sweden—A
qualitative
study.
Frontiers
in
Veterinary
Science,
7,
https://doi.org/10.3389/fvets.2020.619030
Brüssow, H. (2024). The antibiotic resistance crisis and the development of new antibiotics. Letters
in Applied Microbiology, 17(7), https://doi.org/10.1111/1751-7915.14510
Carone, G., Bonada, M., Belotti, E. G., D'Angeli, E., Piccardi, A., Doniselli, F. M., Gubertini, G.,
Casali, C., DiMeco, F., & Del Bene, M. (2025). Post-craniotomy infections: A point-by-
point approach. Brain and Spine, 5, 104193. https://doi.org/10.1016/j.bas.2025.104193
Centers for Disease Control and Prevention (CDC). (2022). Antibiotic resistance threats in the
United
States,
U.S.
Department
of
Health
and
Human
Services.
https://www.cdc.gov/drugresistance/biggest-threats.html
Chen, Y. C., Sheng, W. H., Wang, J. T., Chang, S. C., Lin, H. C., Tien, K. L., Hsu, L. Y., & Tsai,
K. S. (2011). Effectiveness and limitations of hand hygiene promotion on decreasing
healthcare-associated
infections.
PLoS
One,
6(11),
e27163.
https://doi.org/10.1371/journal.pone.0027163.
Chetty, S., Reddy, M., Ramsamy, Y., Naidoo, A., & Essack, S. (2019). Antimicrobial stewardship
in South Africa: A scoping review of the published literature. JAC-Antimicrobial
Resistance, 1(3), dlz060. https://doi.org/10.1093/jacamr/dlz060
Chiumia, F. K., Sinjani Muula, A., Chimimba, F., Nyirongo, H. M., Kampira, E., & Khuluza, F.
(2025). Substandard antibiotics and their clinical outcomes among hospitalized patients in
southern Malawi: A pilot study. Frontiers in Pharmacology, 16, 1535501.
https://doi.org/10.3389/fphar.2025.1535501
Chokshi, A., Sifri, Z., Cennimo, D., & Horng, H. (2019). Global contributors to antibiotic
resistance.
Journal
of
Global
Infectious
Diseases,
11(1),
36–42.
https://doi.org/10.4103/jgid.jgid_110_18
Chuchu, V. M., Njung’e, J., Muasa, B., Gathira, M., Olela, G., Bubi, K. S., Ashaba, J., Githii, S.,
Ndanyi, R., Tanui, E., Irungu, J. I., Azegele, A., Kadam, R., & Ferreyra, C. (2024). Progress
made in digitalizing antimicrobial resistance surveillance in a One Health approach in
Kenya.
Frontiers
in
Public
Health,
12,
https://doi.org/10.3389/fpubh.2024.1411962
ECDC. (2020). Surveillance of antimicrobial resistance in Europe.
EMA. (2020). Sales of veterinary antimicrobial agents in 31 European countries in 2018.
Fleming Fund. (2021). Annual Report.
Gandra, S., Barter, D. M., & Laxminarayan, R. (2020). Economic burden of antibiotic resistance
in ESKAPE organisms in India: A retrospective, observational study. Clinical Infectious
Diseases, 72(1), e42–e48. https://doi.org/10.1093/cid/ciaa008.
Gandra, S., Vasudevan, A. K., Warren, D. K., & Singh, S. K. (2024). Strengthening hospital
epidemiology & infection prevention research capacity in India to curb antimicrobial
resistance.
Indian
Journal
of
Medical
Research,
159(1),
7–9.
https://doi.org/10.4103/ijmr.ijmr_1919_23.
GARDP. (2022). Annual Review.
Graham, C. L. B., Akligoh, H., Ori, J. K., Adzaho, G., Salekwa, L., Campbell, P., Saba, C. K. S.,
Landrain, T. E., & Santolini, M. (2023). Education-based grant programmes for bottom-up
distance learning and project catalysis: Antimicrobial resistance in Sub-Saharan Africa.
Access Microbiology, 5(3), acmi000472.v3. https://doi.org/10.1099/acmi.0.000472.v3.
Gunjan, G., Pandey, R. P., Himanshu, H., Kaur, K., Ahmad, S., Mukherjee, R., & Chang, C.-M.
(2024). Antimicrobial resistance burden in India and Germany in 2022: A systematic
analysis
along
with
One
Health
perspective.
Heliyon,
10(18),
e37910.
https://doi.org/10.1016/j.heliyon.2024.e37910
Jain, P., Bepari, A. K., Sen, P. K., Rafe, T., Imtiaz, R., Hossain, M., & Reza, H. M. (2021). High
prevalence of multiple antibiotic resistance in clinical E. coli isolates from Bangladesh and
prediction of molecular resistance determinants using WGS of an XDR isolate. Scientific
Reports, 11, 22859. https://doi.org/10.1038/s41598-021-02251-w
Karnwal, A., Jassim, A. Y., Mohammed, A. A., Al-Tawaha, A. R. M. S., Selvaraj, M., & Malik,
T. (2025). Addressing the global challenge of bacterial drug resistance: Insights, strategies,
and
future
directions.
Frontiers
in
Microbiology,
16,
Article
https://doi.org/10.3389/fmicb.2025.1517772
Kumar, S., Mahato, R. P., Ch, S., & Kumbham, S. (2025, March). Current strategies against
multidrug-resistant Staphylococcus aureus and advances toward future therapy. The
Microbe, 6, 100281. https://doi.org/10.1016/j.microb.2025.100281
Larsson, D. G. J., & Flach, C. F. (2022). Antibiotic resistance in the environment. Nature Reviews
Microbiology, 20(5), 257–269. https://doi.org/10.1038/s41579-021-00649-x
Laxminarayan, R., Matsoso, P., Pant, S., Brower, C., Røttingen, J.-A., Klugman, K., & Davies, S.
(2016). Access to effective antimicrobials: A worldwide challenge. The Lancet,
387(10014), 168-175. https://doi.org/10.1016/S0140-6736(15)00474-2
Laxminarayan, R., Sridhar, D., Blaser, M., Wang, M., & Woolhouse, M. (2016a). Achieving
global
targets
for
antimicrobial
resistance.
Science,
353(6302),
874–875.
https://doi.org/10.1126/science.aaf9286
Li, W., Yan, Y., Chen, J., Sun, R., Wang, Y., Wang, T., Feng, Z., Peng, K., Wang, J., Chen, S.,
Luo, Y., Li, R., & Yang, B. (2021). Genomic characterization of conjugative plasmids
carrying the mcr-1 gene in foodborne and clinical strains of Salmonella and Escherichia
coli. Food Control, 130, 108032. https://doi.org/10.1016/j.foodcont.2021.108032
Littmann, J., Viens, A. M., & Silva, D. S. (2020). The Super-Wicked Problem of Antimicrobial
Resistance. In E. Jamrozik & M. Selgelid (Eds.), Ethics and Drug Resistance: Collective
Responsibility fo


DOWNLOAD PDF

Back


Google Scholar logo
Crossref logo
ResearchGate logo
Open Access logo
Google logo