IIARD International Institute of Academic Research and Development

INTERNATIONAL JOURNAL OF MEDICAL EVALUATION AND PHYSICAL REPORT (IJMEPR )

E-ISSN 2579-0498
P-ISSN 2695-2181
VOL. 9 NO. 2 2025
DOI: 10.56201/ijmepr.v9.no2.2025.pg13.24

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An Assessment of the Efficacy of Anti-Hypertensive Drugs Via Supersaturated Design.

Nnoka, Love Cherukei, Eleonu, Blessing Chikaodi

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Abstract

The study investigated the efficacy of ten anti- hypertensive drugs as declared by their users. The data for this study were sourced through a carefully structured questionnaire and administered to 455 respondents at four strategic locations in Rivers State of Nigeria; (Emohua, Ahoada, Khana and Etche). The variables were separated into “Factors” and “Runs” and two- level supersaturated designs (SSDs) were considered and coded as -1 and 1 signifying low and high levels respectively. The study also recognized a well-known criterion for evaluating the efficacy of supersaturated design (SSD); E(S2). The drugs with equivalent efficacy levels were merged and represented by the higher or lower of them all depending on the case. The repeated or duplicated experimental “Runs” (drugs) were interchanged for “Factors” and were eliminated to allow for only a unique column thereby preserving orthogonality principle. Thus, with the drugs as “Factors” we were able to obtain 4 x 6 design matrix representing 4 “Runs” AND 6 “Factors”. The study identified the most “active factor” given the 6 “factors” (the most efficacious) of the drugs.

keywords:

Runs, Factors, Supersaturated, Anti-hypertensive drugs & Efficacy

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