IIARD International Institute of Academic Research and Development

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH (IJHPR )

E-ISSN 2545-5737
P-ISSN 2695-2165
VOL. 10 NO. 3 2025
DOI: 10.56201/ijhpr.vol.10.no3.2025.pg1.8

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Changes in Immunology of Guinean Tilapia ( Coptodon guineensis) Exposed to Glyphosate in the Laboratory

Amachree, D, Akinrotimi OA, Ayaobu-Cookey IK, Orokotan OO, Owhonda KN, and Omodu, FA

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Abstract

This study assessed immunological alterations in two sizes of Coptodon guineensis exposed to glyphosate at five concentrations: 0.00 (control), 0.05, 0.10, 0.15, and 0.20 mg/L for a period of 15 days. During the experiment six water quality variables which include: temperature, pH, salinity, dissolved oxygen, nitrite, and ammonia were evaluated. After the experiment, blood samples were taken from the fish, which were examined for immunological profiles using standard laboratory techniques. The results showed that the chemical had a negative impact on the exposed fish based on all the parameters that were assessed. Additionally, the results demonstrated that the values for nitrite and ammonia increased in direct proportion to the chemical's concentration. Meanwhile, there was a sharp decline in the values of dissolved oxygen (P<0.05). While, salinity, pH, and temperature were within the same range. The results also indicated a significant (P<0.05) reduction in the values of thrombocytes, leucocrit, lymphocytes and monocytes. While, white blood cells, neutrophils and eosinophils were significantly (p<0.05) elevated compared to the control values. According to the study, the chemical's impact on the immunological profiles of the fish varies with the concentrations of the chemical. Applying this chemical near an aquatic environment should therefore be done with caution.

keywords:

Immune systems, Contaminants Tilapia, Fish, Aquatic environment

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