IIARD International Institute of Academic Research and Development

JOURNAL OF BIOLOGY AND GENETIC RESEARCH (JBGR )

E-ISSN 2545-5710
P-ISSN 2695-222X
VOL. 11 NO. 1 2025
DOI: 10.56201/jbgr.vol.11.no1.2025.pg44.53

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Evaluation of Antibacterial Activity of Parkia biglobosa (African Locust Beans) Extracts against Multidrug Resistant Salmonella Species

Abba SA, Yusha’u M, Sadisu FU, Ahmed I and Usman UZ

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Abstract

There is global resurgence in the use of herbal preparations and in some developing countries like Nigeria and it is being gradually integrated into the primary and secondary health care systems. The study aimed to evaluate the antibacterial activity of P. biglobosa leaf extracts against clinical isolates of Salmonella species. Phytochemical screening of the extracts was conducted using conventional method. Agar well diffusion method was used to evaluate the antibacterial activity of the extract while broth dilution method was employed for determination of Minimum inhibitory concentration (MIC). The results showed presence of flavonoids, terpenoids, tannins, alkaloids, cardiac glycosides and anthraquinones. Antibacterial activity of the extract show activity against the test isolates, with the inhibition zones increasing with concentration. The n-hexane extracts generally exhibits a higher inhibitory effect (with average activity of 12.5mm) compared to the aqueous extract (10.6mm). The MIC of the extracts indicated that the n-hexane extract inhibited the growth of the isolate at 12.5 – 25 mg/ml while aqueous extract at 25 – 50 mg/ml. the MBC of n-hexane extract ranges from 12.5 – 50 mg/ml while aqueous extract ranges from 25 – 75 mg/ml. It is concluded that the extract of P. biglobosa leaf was active against Salmonella species isolated from gastrointestinal infection patients

keywords:

Antibacterial activity, multidrug resistance, Parkia biglobosa, Salmonella

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