Medicinal Importance of Dithiocarbamate Complexes: Potential Agents in Management of Diabetes
Abstract
s Recent studies in bioinorganic chemistry and drug design have revealed the role of transition metal complexes as therapeutic compounds and diagnostic agent in medicine. Dithiocarbamates are organosulphur ligands which have the ability to form stable complexes with transition metals, and this chelating ability has been utilized in numerous applications. Their application as anticancer, antimicrobial, medical imaging and anti-inflammatory agents have been reported. According to World Health Organization (WHO) about 422 million people worldwide have diabetes, the majority living in low-and middle-income countries, and 1.5 million deaths are directly attributed to diabetes each year. Increasing resistance to available drugs and their associated side-effects have drawn wide attention towards designing alternative therapeutic strategies for control of hyperglycemia and oxidative stress The development of antidiabetic metal complexes replacing insulin injection to regulate sugar levels appears to be promising. The administration of vanadium and zinc in form of inorganic salt to control glucose level in the blood plasma have been achieved. This article reviews the applications of dithiocarbamate and its metal complexes as potential agent in the management of diabetes.
Keywords
dithiocarbamate
complex
diabetes
medicine
References
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