IIARD International Institute of Academic Research and Development

INTERNATIONAL JOURNAL OF MEDICAL EVALUATION AND PHYSICAL REPORT (IJMEPR )

E-ISSN 2579-0498
P-ISSN 2695-2181
UNKNOWN_VOLUME
DOI: 10.56201/ijmepr.v8.no6.2024.pg

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Histopathological Study of Thyroid Nodules: Correlation with Fine Needle Aspiration Cytology

khudhair Amer Dalia and Zainab Hayder Jaber Alkufaishi

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Abstract

Objective: This study is of paramount importance as it aims to evaluate the diagnostic accuracy of Fine Needle Aspiration Cytology (FNAC) in diagnosing thyroid nodules. By correlating the cytological findings with histopathological outcomes, we can better understand the limitations and advantages of FNAC in clinical practice, a crucial area of research for medical professionals. Materials and Methods: This retrospective study was conducted on 150 patients who underwent thyroidectomy after FNAC at a private hospital in Baghdad. The cytological findings were classified using the Bethesda System for Reporting Thyroid Cytopathology, and the histopathological diagnoses were considered the gold standard for comparison. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall diagnostic accuracy were calculated.

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References:

Cibas ES, Ali SZ. The Bethesda System for Reporting Thyroid Cytopathology.
Thyroid. 2009;19(11):1159-65.
Burch HB, et al. The role of fine-needle aspiration biopsy in evaluating thyroid nodules:
A 2016 clinical practice guideline from the American Thyroid Association. Thyroid.
2016;26(1):1-25.
Hwang J, et al. Impact of ultrasound-guided fine-needle aspiration on the diagnostic
yield of thyroid nodules: A single-center experience. Endocr Pract. 2013;19(6):1002-8.
Nikiforov YE, et al. Thyroid cancer: the role of molecular diagnostics. J Clin
Endocrinol Metab. 2013;98(3):1051-61.
Wang C, et al. Diagnostic value of ultrasound elastography for differentiating malignant
and benign thyroid nodules: A meta-analysis. Eur J Radiol. 2018;102:41-50.
Chudova D, et al. A novel gene expression classifier for diagnosing indeterminate
thyroid nodules: A multicenter validation study. Thyroid. 2019;29(4):529-35.
Trimble CL, et al. The importance of molecular testing for the evaluation of thyroid
nodules. Thyroid. 2019;29(12):1690-9.
American Thyroid Association. Thyroid Nodules: A Patient’s Guide. [Internet].
Available
from:
https://www.thyroid.org/patient-thyroid-information/patient-
brochures/thyroid-nodules/
Gharib H, et al. A multi-disciplinary approach to managing thyroid nodules: An
endocrine surgery perspective. Ann Surg Oncol. 2015;22(7):2416-24.
Koo S, et al. The diagnostic value of molecular testing for indeterminate thyroid
nodules: A systematic review and meta-analysis. Ann Surg Oncol. 2020;27(2):538-48.
Lee S, et al. The role of fine-needle aspiration cytology in diagnosing thyroid cancer:
A systematic review and meta-analysis. Head Neck. 2015;37(5):738-47.
La Vecchia C, et al. Thyroid cancer epidemiology. Endocr Relat Cancer. 2016;23(3).
Kwan K, et al. Risk of malignancy in thyroid nodules with indeterminate cytology: A
systematic review and meta-analysis. J Clin Endocrinol Metab. 2017;102(11):3508-16.
Krane JF, et al. Fine-needle aspiration cytology of thyroid nodules: A review of the
literature. Cancer Cytopathol. 2017;125(7):489-95.
Grubbs EG, et al. Contemporary management of thyroid nodules: The role of fine-
needle aspiration biopsy. Cancer Control. 2018;25(1):1073274818791401.
Chen L, et al. Ultrasonography-guided fine-needle aspiration of thyroid nodules: A
comprehensive review of the literature. J Clin Endocrinol Metab. 2017;102(4):1393-
Tufano RP, et al. A review of the treatment of well-differentiated thyroid cancer. J Surg
Oncol. 2015;111(1):109-14.
Nascimento C, et al. Papillary thyroid carcinoma: A review of recent developments. J
Clin Oncol. 2017;35(26):2992-3000.
Ali SZ, et al. The value of fine-needle aspiration biopsy in diagnosing thyroid
neoplasms: A 30-year retrospective study. Thyroid. 2006;16(2):189-94.
Eskiocak A, et al. The accuracy of fine needle aspiration cytology in diagnosing thyroid
cancer: A prospective study. J Endocrinol Invest. 2014;37(9):839-44.
Nikiforov YE, et al. Diagnosis of follicular neoplasms in thyroid nodules: Current
practices and future directions. J Clin Endocrinol Metab. 2014;99(5).
Gharib H, et al. Thyroid nodules: A review of the literature. J Clin Endocrinol Metab.
2005;90(5):2589-96.
Machens A, et al. Surgical management of thyroid cancer: A review of the literature.
Langenbecks Arch Surg. 2013;398(7):961-70.
Hennessey JV, et al. A review of the role of fine-needle aspiration biopsy in managing
thyroid nodules. Endocrine. 2018;62(3):628-33.
Haugen BR, et al. 2015 American Thyroid Association Management Guidelines for
Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid.
2016;26(1):1-133.
Pottorff A, et al. Molecular diagnostics in the management of thyroid cancer: An
overview. Thyroid. 2017;27(3):345-52.
Van Dijk JD, et al. An update on managing indeterminate thyroid nodules: The role of
molecular testing. Endocrine. 2019;66(2):326-34.
Sosa JA, et al. Thyroid cancer incidence and mortality in the United States: A 30-year
perspective. Surgery. 2011;149(6):839-44.
Baloch ZW, et al. The fine needle aspiration of thyroid nodules: A consensus statement.
Cytopathology. 2016;27(2):121-9.
Tashjian AH, et al. The role of molecular diagnostics in managing thyroid nodules:
Current evidence and future directions. J Clin Endocrinol Metab. 2018;103(12):4609-
Baghai M, et al. Evaluation of the role of fine-needle aspiration cytology in diagnosing
thyroid nodules. J Surg Oncol. 2016;113(5):650-6.
Alexander EK, et al. Preoperative ultrasound in the evaluation of thyroid nodules: A
prospective study. J Clin Endocrinol Metab. 2015;100(9):3722-9.

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