IIARD International Institute of Academic Research and Development

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH (IJHPR )

E-ISSN 2545-5737
P-ISSN 2695-2165
VOL. 9 NO. 4 2024
DOI: 10.56201/ijhpr.v9.no4.2024.pg71.79

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Evaluation Of Some Antioxidant Activity in Induced Prostatitis Following Treatment with Moringa Oleifera

Julie Cookey, George Gborienemi

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Abstract

Prostatitis has been observed to be common among men and efforts on therapeutic approach using local plants for management have attained a significant insight in research. In this work, using animal mode, Benign Prostate Hyperplasia (BPH) was induced with testosterone and the progress was monitored by treating with extract of Moringa oleifera. The enzymatic activities of three antioxidants were monitored spectrophotometrically and evaluated. An increased antioxidant activity was observed for Malondialdehyde (MDA), Sodium Dismutase (SOD) and Glutathione (GSH) which is suggestive of ameliorative property of Moringa Oleifera. With a P-value set at 0.05, a significant difference was observed for mean GSH on day 10, 20 and 25 in concentration. Similar observation was seen in Malondialdehyde and SOD.

keywords:

Antioxidant, Prostatitis, Treatment, Moringa Oleifera.

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References:

A.K.M. Asaduzzaman, Imtiaj Hassan, Aninda Chakrabortty, Sadnima Zaman, Shaikh
Shodidul Islam (2018). Moringa Oleifera Seed Lectin Inhibits Ehrhich Ascites
Carcinoma Cell Growth Inducing Apoptosis Through the Regulation of Bak and NF-KB
gene expression. International Journal of Biological Macromolecules Vol. 107, Part B,
1936-1944.
Abd Eldaim N. Shaban Abd Elras Abd Elaziz S. (2017). An aqueous extract from
Moringa Oleifera leaves a meliorates hepatotoxity in aloxan induced diabetic rats.
Biochem cell Bio (2017) 95:
Abd H.H., Ahmed H.A., Mutar F.T., (2020), Moringa Oleifera Leaves-Extract Modulate
Toxicity, Sperm Alterations, Oxidative Stress and Testicular Damage Induced by
Tramadol in Male Rats. Toxicol Res. 9, 101-106.
Abdilahi H., Van Staden, J. South, (2012). African Plants and Male Reproductive
Healthcare: Concept and Contraception J. Ethnopharmacol 143, 475 - 480.
Deka P.K., Sarma S (2010). Psychological aspect of Infertility. Br. J. Med. Pract 3, 336.
Dosumu O. Akinloye D. Onunkwor O, Thomas F. Adeyemo R (2021). Time course study
of combined n-acetyl-p- aminophenol and diglophenac induced – hepatotoxicity and
oxidative stress Winstar rats. S. chem. Soc Nigeria (2021) 46: 400-8
Ek-bakry K, Toson E, Serag M, Abosen M. (2016). Hepatoprotective effect of Moringa
Oleifera leaves extract against carbon tetrachloride – induced liver damage in rats. World
J. Pharm. Pharm Sci (2016) 5:76-89
Gouda A. EL. Nabarwy N. Ibrahim S. Moringa Oleifera extract alternates Aluminum
Phosphide-induced Acute Cardiac Toxicity in Rats. Toxicol Rep (2018) 5: 209-12
Kou X, Li B, Olayanju J. Drake I, Chen N. (2018), Neutracentrical or Pharmacological
potential of M.O. Lam. Nutrients (2018) 10:343.
Kou X, Li B, Olayanju JB, Drake JM and Chen N. (2018). Nutraceutical Potential of
Moringa Oleifera Lan. Nutrients; 10 (3) 343-355
Madersbacher S, Sampson N. Guligz, (2019) Pathophysiology of Benign Prostatic
Hyperplasia and Benign Prospstate Enlargement. A Mini-Review. Gerontology. 65, 458-
Misra HP, Fridovich I, (1989). The role of Superoxide Anion in the Autoxidation of
Epinephrine and Simple Assay for Superoxide Dismutase. Journal of Biological
Chemistry, 247(10), 3170-3175.
Obembe O.O., (2019). Sex Hormones and Oxidative Stress Biomolecules of Male Wistar
Rats Treated with Moringa Oleifera Seed Fraction. JBRA Assisted Reproduction. 23(4),
408-413.
Saki, M., De Villiers H., Ntsapic, and Tiloke, C (2023). The Hepatoprotective Effects of
Moringa Oleifera Against Antinetroviral-Induced Cytotoxicity in HEPG2 Cells. A
Review. Plants 12(18), 3235-3260.
Salama AA, Etseid AA, Awad, OM (2020). Effects of Morginga Oleifera leaves extract
against electromagnetic field impairments on hemoglobin and testes of rat. Biosci Appl.
Res 6; 132-141
Sodamade A., Bolaji O.S., and Adeboye O.O., (2013). Proximate Analysis, Mineral
Contents and Functional Properties of Moringa Oleifera Leaf Protein Concentration.
IOSR Journal of Applied Chemistry 4(6), 47-51.
Sreelatha S, Padma PR (2009). Activity and total phenolic content of Moringa Oleifera
leaves in two stages of maturity. Plant food. Hum Nutr 64, 303-311
Tarmam El-Ehmat, Bara Jarwan, Aref Zayed, Ahmed Alhustan, Moxha Syof (2018).
Biochemical Evaluation of Selected Grape Varieties (Vitus Vinifera) Grown in Jordan
and in Vitro Evaluation of Grape Seed Extract on Human Prostate Cancer. Food
Bioscience Vol. 24, 103-110.
Vargas – Sanchez K, Gray – Jaraamilo E, and Gonzalez – Reyes R. F(2019), Effects of
Moringa Oleifera on Glyceamic and lusulin levels: A review of animal and Human
studies, Nutrients 11(12) 2907 – 2921.
Xiang P, Liu D, Guan D. Zhen Du, Hao Y, Wang M. Ping H (2021). Identification of the
key genes in benign prostate hyperplasia using broinformalics analysis. World Journal of
Urology 9,(10), 7 – 21
Younus H (2018). Therapentic Potentials of Superoxide dismutase. International
Journals of Health Science (Qassim). 12(3), 88 – 93
Zarrah A.D., Krugger T.F., (2018). The Challenges of Supporting Male Unfertility
Treatment in South Africa. Nat. Rev. Urol 15, 719-720.
Zheng B. Luo J, Wang P, Yang L, Chem T, Sun J,Xie M, Zhaug H, (2019). The beneficial
effects of Moringa Oleifera leaf in reproductive performance in mice. Food science and
nutrition 7 (2) 738-746

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