INTERNATIONAL JOURNAL OF MEDICAL EVALUATION AND PHYSICAL REPORT (IJMEPR )

E-ISSN 2579-0498
P-ISSN 2695-2181
VOL. 8 NO. 6 2024
DOI: 10.56201/ijmepr.v8.no6.2024.pg36.46


Incidence of a Fungal Infection in An Individual who has Received a Cancer Diagnosis. (Review Article)

Doaa Abd Alabas Muhammad ridh , Fatima Ibrahim Mohammad, Osama Faisal Kokaz


Abstract


Up To Date fungal infections are linked to cancer development in different part of human body. This association frequently seen in individuals has immune system issues and elderly people. Microbial infections in charge of more than 2 million of cancer cases. Invasive fungal infection sustains cancer growth rate and needed to scrutinized. The commonest genus and species of fungi involved are Candida albicans, Candida tropicalis, Aspergillus flavus, Fusarium proliferatum and others. Oral candidiasis consumes the vast majority of oral fungal infections specially when combined with receiving a cancer therapy. This review deals with risk of oral candida and their role in progressing of oral cancer beside co-factors like health status, alcohol, smoking and immune deficiency.


keywords:

Fungal infection, Candida albicans, Cancers and Candidiasis.


References:


Abati, S., Bramati, C., Bondi, S., Lissoni, A., & Trimarchi, M. (2020). Oral cancer and precancer:
A narrative review on the relevance of early diagnosis. International Journal of
Environmental Research and Public Health, 17(24), 1–14.
https://doi.org/10.3390/ijerph17249160
Arzmi, M. H., Cirillo, N., Lenzo, J. C., Catmull, D. V., O’Brien-Simpson, N., Reynolds, E. C.,
Dashper, S., & McCullough, M. (2019). Monospecies and polymicrobial biofilms
differentially regulate the phenotype of genotype-specific oral cancer cells. Carcinogenesis,
40(1), 184–193. https://doi.org/10.1093/carcin/bgy137
Ayuningtyas, N. F., Mahdani, F. Y., Pasaribu, T. A. S., Chalim, M., Ayna, V. K. P., Santosh, A.
B. R., Santacroce, L., & Surboyo, M. D. C. (2022). Role of Candida albicans in Oral
Carcinogenesis. Pathophysiology, 29(4), 650–662.
https://doi.org/10.3390/pathophysiology29040051
Bakri, M. M., Hussaini, H. M., Holmes, A., Cannon, R. D., & Rich, A. M. (2010). Revisiting the
association between candidal infection and carcinoma, particularly oral squamous cell
carcinoma. Journal of Oral Microbiology, 2(2010). https://doi.org/10.3402/jom.v2i0.5780
Bassetti, M., Giacobbe, D. R., Vena, A., & Wolff, M. (2019). Diagnosis and Treatment of
Candidemia in the Intensive Care Unit. Seminars in Respiratory and Critical Care Medicine,
40(4), 524–539. https://doi.org/10.1055/s-0039-1693704
Birman, E. G., Kignel, S., Da Silveira, F. R. X., & Paula, C. R. (1997). Candida albicans:
Frequency and characterization in oral cancer (Stage I) from smokers and drinkers. Revista
Iberoamericana de Micologia, 14(3), 101–103.
Bornstein, J. (2019). Vulvar Disease: Breaking the Myths. In Vulvar Disease: Breaking the Myths
(Issue Vvc). https://doi.org/10.1007/978-3-319-61621-6
Di Cosola, M., Cazzolla, A. P., Charitos, I. A., Ballini, A., Inchingolo, F., & Santacroce, L. (2021).
Candida albicans and oral carcinogenesis. A brief review. Journal of Fungi, 7(6).
https://doi.org/10.3390/jof7060476
Findley, K., Oh, J., Yang, J., Conlan, S., Deming, C., Meyer, J. A., Schoenfeld, D., Nomicos, E.,
Park, M., Becker, J., Benjamin, B., Blakesley, R., Bouffard, G., Brooks, S., Coleman, H.,
Dekhtyar, M., Gregory, M., Guan, X., Gupta, J., … Segre, J. A. (2013). Topographic diversity
of fungal and bacterial communities in human skin. Nature, 498(7454), 367–370.
https://doi.org/10.1038/nature12171
Forche, A., Alby, K., Schaefer, D., Johnson, A. D., Berman, J., & Bennett, R. J. (2008). The
parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the
formation of recombinant strains. PLoS Biology, 6(5), 1084–1097.
https://doi.org/10.1371/journal.pbio.0060110
Fortún, J., Martín-Dávila, P., Gómez-García de la Pedrosa, E., Pintado, V., Cobo, J., Fresco, G.,
Meije, Y., Ros, L., Alvarez, M. E., Luengo, J., Agundez, M., Belso, A., Sánchez-Sousa, A.,
Loza, E., & Moreno, S. (2012). Emerging trends in candidemia: A higher incidence but a
similar outcome. Journal of Infection, 65(1), 64–70.
https://doi.org/10.1016/j.jinf.2012.02.011
Ghannoum, M. A., Jurevic, R. J., Mukherjee, P. K., Cui, F., Sikaroodi, M., Naqvi, A., & Gillevet,
P. M. (2010). Characterization of the oral fungal microbiome (mycobiome) in healthy
individuals. PLoS Pathogens, 6(1). https://doi.org/10.1371/journal.ppat.1000713
Goldman, M., Cloud, G. A., Wade, K. D., Reboli, A. C., Fichtenbaum, C. J., Hafner, R., Sobel, J.
D., Powderly, W. G., Patterson, T. F., Wheat, L. J., Stein, D. K., & Dismukes, W. E. (2005).
A randomized study of the use of fluconazole in continuous versus episodic therapy in
patients with advanced HIV infection and a history of oropharyngeal candidiasis: AIDS
clinical trials group study 323/mycoses study group study 40. Clinical Infectious Diseases,
41(10), 1473–1480. https://doi.org/10.1086/497373
Inchingolo, F., Santacroce, L., Ballini, A., Topi, S., Dipalma, G., Haxhirexha, K., Bottalico, L., &
Charitos, I. A. (2020). Oral cancer: A historical review. International Journal of
Environmental Research and Public Health, 17(9). https://doi.org/10.3390/ijerph17093168
Irani, S. (2016). Pre-Cancerous Lesions in the Oral and Maxillofacial Region: A Literature Review
with Special Focus on Etiopathogenesis. Iranian Journal of Pathology, 11(4), 303–322.
Kabir, M. A., & Ahmad, Z. (2013). Candida Infections and Their Prevention . ISRN Preventive
Medicine, 2013(Vvc), 1–13. https://doi.org/10.5402/2013/763628
Keighley, C. L., Pope, A., Marriott, D. J. E., Chapman, B., Bak, N., Daveson, K., Hajkowicz, K.,
Halliday, C., Kennedy, K., Kidd, S., Sorrell, T. C., Underwood, N., van Hal, S., Slavin, M.
A., & Chen, S. C. A. (2021). Risk factors for candidaemia: A prospective multi-centre case-
control study. Mycoses, 64(3), 257–263. https://doi.org/10.1111/myc.13211
Klis, F. M., Sosinska, G. J., De Groot, P. W. J., & Brul, S. (2009). Covalently linked cell wall
proteins of Candida albicans and their role in fitness and virulence. FEMS Yeast Research,
9(7), 1013–1028. https://doi.org/10.1111/j.1567-1364.2009.00541.x
Krogh, P., Hald, B., & Holmstrup, P. (1987). Possible mycological etiology of oral mucosal
cancer: Catalytic potential of infecting candida aibicans and other yeasts in production of N-
nitrosobenzylmethylamine.
Carcinogenesis,
8(10),
1543–1548.
https://doi.org/10.1093/carcin/8.10.1543
Kumar, S., Mishra, P., Warhekar, S., Airen, B., Jain, D., & Godha, S. (2014). Oral health status
and oromucosal lesions in patients living with HIV/AIDS in India: A comparative study.
AIDS Research and Treatment, 2014. https://doi.org/10.1155/2014/480247
Lam-ubol, A., Rungsiyanont, S., Vacharotayangul, P., Sappayatosok, K., & Chankanka, O. (2019).
Oral manifestations, salivary flow rates and Candida species in Thai HIV-infected patients.
Journal
of Clinical and Experimental Dentistry, 11(2), e138–e145.
https://doi.org/10.4317/jced.55384
Mahalingam, S. S., Jayaraman, S., & Pandiyan, P. (2022). Fungal Colonization and Infections—
Interactions
with Other Human Diseases. Pathogens, 11(2), 1–16.
https://doi.org/10.3390/pathogens11020212
Markopoulos, A. K. (2012). Current Aspects on Oral Squamous Cell Carcinoma. The Open
Dentistry Journal, 6(1), 126–130. https://doi.org/10.2174/1874210601206010126
Mehanna, H., Beech, T., Nicholson, T., El-Hariry, I., McConkey, C., Paleri, V., & Roberts, S.
(2013). Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head
and neck cancer-systematic review and meta-analysis of trends by time and region. Head and
Neck, 35(10), 1391. https://doi.org/10.1002/HED
Mishra, P., Bolard, J., & Prasad, R. (1992). Emerging role of lipids of Candida albicans, a
pathogenic dimorphic yeast. Biochimica et Biophysica Acta (BBA)/Lipids and Lipid
Metabolism, 1127(1), 1–14. https://doi.org/10.1016/0005-2760(92)90194-Z
Mizumoto, A., Ohashi, S., Hirohashi, K., Amanuma, Y., Matsuda, T., & Muto, M. (2017).
Molecular mechanisms of acetaldehyde-mediated carcinogenesis in squamous epithelium.
International
Journal of Molecular Sciences, 18(9), 1–12.
https://doi.org/10.3390/ijms18091943
Mohamed, A. A., Lu, X. L., & Mounmin, F. A. (2019). Diagnosis and Treatment of Esophageal
Candidiasis: Current Updates. Canadian Journal of Gastroenterology and Hepatology, 2019.
https://doi.org/10.1155/2019/3585136
Murciano, C., Moyes, D. L., Runglall, M., Islam, A., Mille, C., Fradin, C., Poulain, D., Gow, N.
A. R., & Naglik, J. R. (2011). Candida albicans cell wall glycosylation may be indirectly
required for activation of epithelial cell proinflammatory responses. Infection and Immunity,
79(12), 4902–4911. https://doi.org/10.1128/IAI.05591-11
Nobile, C. J., & Johnson, A. D. (2015). Candida albicans Biofilms and Human Disease. Annual
Review of Microbiology, 69(1), 71–92. https://doi.org/10.1146/annurev-micro-091014-
104330
Osaigbovo, I.


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