IIARD International Institute of Academic Research and Development

INTERNATIONAL JOURNAL OF MEDICAL EVALUATION AND PHYSICAL REPORT (IJMEPR )

E-ISSN 2579-0498
P-ISSN 2695-2181
VOL. 8 NO. 6 2024
DOI: 10.56201/ijmepr.v8.no6.2024.pg20.35

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Evaluation of Some Cardio-Inflammatory, Hepato-Renal, Reproductive Hormones and Oxidative Stress Biomarkers among Post-menopause Women in Amassoma, Bayelsa State, Nigeria

Egoro Emmanuel Tonbra, Oni Emmanuel Sunday, Ilegbedion Ikhide Godwin

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Abstract

Menopause is a permanent menstruation cessation which results in the inability of many women to conceive children. This study was aimed on some evaluation of cardio-inflammatory, hepato- renal, reproductive hormones, and oxidative stress biomarkers among post-menopause women in Amassoma, Bayelsa State, Nigeria. Five milliliter of blood specimen were collected via venipuncture technique from each of the one hundred and seventeen women who were selected for this study and categorized into three groups: experimental group one made up of 39 post- menopause women within the age bracket of 52 and 60 who had undergone menopause for less than 5 years, experimental group two made up of 39 post-menopause women within age bracket of 52 and 60 who had undergone menopause for 5-7 years and 39 non-menopausal women within the age bracket of 31 to 42 years who served as control group. The blood specimens were dispensed into lithium heparin anti-coagulated bottles respectively and spun at 2,500 revolution/minute with the obtained plasma used for the measurement of the following biomarkers: troponin-1 (immune turbidimetric method), creatinineKinase-MB (immune inhibition method), C- reactive protein (latex turbidimetry method), interleukin-6 (elascience method), alanine aminotransferase (colorimetric method), aspartate aminotransferase(colorimetric method), urea (urease berthelot method), creatinine (Jaffe reaction method), estradiol (liquid chromatography- tandem mass spectrometry method), follicle stimulating hormone (enzyme linked immunosorbent assay), progesterone (enzyme linked immunosorbent assay), malondialdehyde (thiobarbituric acid method) and glutathione peroxidase(ultra violet method). The data obtained from these measurements were analyzed using SPSS version 23.0 as statistical package and the differences between the groups assessed using student “t” test which were considered significant at a p-value lesser than 0.05. The results in e

keywords:

Evaluation, cardio-inflammatory, hepato-renal, reproductive hormones, oxidative

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