IIARD International Institute of Academic Research and Development

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH (IJHPR )

E-ISSN 2545-5737
P-ISSN 2695-2165
VOL. 9 NO. 4 2024
DOI: 10.56201/ijhpr.v9.no4.2024.pg37.46

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Cardiac Dysfunction and Mitochondrial Impairment in A Rat Model of Doxorubicin-Induced Cardiotoxicity

Araa Mahdi Hussein AI-Rubaye

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Abstract

Doxorubicin (DOX) is an effective chemotherapeutic agent widely used to treat various cancers. However, its clinical use is significantly dependent cardiotoxic effects, which lead to cardiac dysfunction and mitochondrial impairment. This study investigates the relationship between DOX-induced cardiotoxicity and mitochondrial dysfunction in a rat model. Key cardiac function parameters and mitochondrial oxidative stress markers were assessed to determine the impact of DOX treatment. The results reveal significant deterioration in cardiac function and mitochondrial integrity, suggesting that mitochondrial damage is central to DOX-induced cardiotoxicity.

keywords:

DOX, Rat, Cardiotoxicity

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