IIARD International Institute of Academic Research and Development

INTERNATIONAL JOURNAL OF CHEMISTRY AND CHEMICAL PROCESSES (IJCCP )

E-I SSN 2545-5265
P- ISSN 2695-1916
VOL. 10 NO. 4 2024
DOI: 10.56201/ijccp.v10.no4.2024.pg32.46

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Effect of Chronic Exposure to Petroleum Products on some HepatoRenal, Toxico-Inflammatory and Cardiac Biomarkers among Auto Mechanics in Mechanic Village Yenagoa, Bayelsa State, Nigeria

Egoro Emmanuel Tonbra, Oni Emmanuel Sunday, Ifenkwe John Chimerenka

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Abstract

Auto-mechanics are skilled professionals that are specialists in auto mechanics, spray painting, panel beating, welding, battery recycling, brazing and repairing radiators and air conditioners. This study was aimed on the effect of chronic exposure to petroleum products on some hepatorenal, toxico-inflammatory and cardiac biomarkers among auto- mechanics in mechanic village Yenagoa Bayelsa State Nigeria. Five milliliters of blood specimen was withdrawn from ninety apparently healthy individuals between 28 and 49 years of age, who were subsequently categorized into experimental group one which consisted of 30 auto-mechanics with less than 10 years working experience, experimental group two which consisted of 30 auto-mechanics with 10- 15 years working experience and control group which consisted of 30 non- auto-mechanics. The blood specimens were dispensed into lithium heparin anti-coagulated bottles respectively, spun at 1,500 revolution/minute and plasma obtained used for the quantitative measurement of aspartate aminotransferase (colorimetric), alanine aminotransferase (colorimetric), urea (urease berthelot), creatinine (Jaffe reaction), lead (atomic absorption spectrophotometry), cadmium (atomic absorption spectrophotometry), C-reactive protein (latex turbidimetry), interleukin-6 (elascience), troponin-1 (dual vial liquid immune turbidimetry) and creatinineKinase (immuneinhibition). The data obtained were analyzed using SPSS 23.0 statistical package with the results expressed as mean ± SD via the use of student “t” test which was considered significant at p < 0.05. No statistically significant differences were shown in the mean values of aspartate aminotransferase (7.16 ± 0.45) U/L, (p = 0.81), alanine aminotransferase (8.27 ± 0.51) U/L, (p = 0.78), urea (4.73 ± 2.22) mmol/L, (p = 0.91), creatinine (77.86 ± 4.13) µmol/L, (p = 0.89), lead (0.13 ± 0.04) x10-2 ppm, (p = 0.81), cadmium (0.10 ± 0.03) x10-2 ppm, (p = 0.97), C-reactive protein (2.80

keywords:

Petroleum products, Biochemical markers, Auto-mechanics, Yenagoa, Bayelsa State, Nigeria

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References:

Abdrabouh, A., El-wakf, A., Hagras, A. and Elgharieb, A. (2017). Health assessment approach for
evaluating haematologic and immune toxicity of prolonged gasoline inhalation in fuel
station workers at Mansoura City, Egypt. Journal of Applied Environmental and
Biological Sciences. 7(8), 30-36.
Ajugwo, A.O., Adias, T.C., Aghatise, K., Fadairo, J.K. and Nyenke, C.U. (2014). Reduced
haematological indices in auto-mechanics and fuel attendants in Elele Nigeria.
American Journal of Medical and Biological Research. 2 (1), 1-4. .
Akram, H.A., Nizar, A/A. and Ali-Yagoob, E.Y. (2017). Effects of petroleum products on renal
function among petroleum filling workers station in El-Obied City. European Journal
of Pharmaceutical and Medical Research. 4 (10), 395-399.
Al-jadaan, S.A.N. and Jabbaralkinany, A.S. (2017). Impact of benzene exposure on lung functions
of fuel station workers in Basra city. Southern of Iraq. International Journal of
Pharmaceutical Science and Healthcare. 2(7), 31-36.
Azza, S.J. and Eman, T.A. (2020). Impact of petroleum exposure on some haematological indices,
interleukin-6 and inflammatory markers of workers at Petroleum Stations in Basra City.
Journal of Environmental and Public Health.2020; 2020, 7693891.
Ben-Chioma, A.E and Nwachukwu, E.O. (2018). Assessment of cadmium, lead and mercury
levels on petrol attendants and welders in Obio-Akpor and Phalga in Rivers State.
International Journal of Contemporary Medical Research. 5(11), K1-K5.
Boritz, Z.S., Michael, T.K. and Robert, A.K. (2008). Air pollution and cardiovascular injury.
Journal of the American College of Cardiology. 52 (9), 719-726.
Christopher, E E., Koofreh, D. and Nyebuk, D. (2013). Effect of gasoline inhalation on menstrual
characteristics and the hormonal profile of female petrol pump workers. Journal of
Environment Protection. 4 (8A), 65-73.
Daupamowei, H.A. (2018). A historical evolution and development of Amassoma seigbein fishing
festival in Central Niger Delta region of Nigeria. Abraka Humanities Reviews. 8(1),
137-158.
Eaten, D.L and Klaassen, C.D. (2001). Principle of toxicology in Klassen C.D. Casaret and Doll’s
Toxicology. The Basic Science of Poison. 6th edition. McGraw-Hill, p. 987.
Egoro, E.T., Ilegbedion, I.G. and Hope, C. (2023). Status of some biochemical markers among
nasal tobacco snuffing addicts in Yenagoa Bayelsa State Nigeria. International Journal
of Medical Evaluation and Physical Report. 7(4), 135-144. Egoro, E.T., Oni, E.S, Otaraku, J.O. and John, D.E. (2021). Studies on some biochemical
parameters among charcoal (Physiculus nematopus) traders in Swali market Yenagoa
Bayelsa State. Sokoto Journal of Medical Laboratory Science. 6(3), 74-80.
Ekpenyong, C. and Asuquo, A. (2017). Recent advances in occupational and environmental health
hazards of workers exposed to gasoline compounds. International Journal of
Occupational Medicine and Environmental Health. 30(1), 1-26.
Emmanuel, T.E. (2020). Effect of indiscriminate consumption of paracetamol (acetaminophen) on
selected biochemical parameters in Rattus norvegicus rats. GSC Biological and
Pharmaceutical Sciences. 13 (03), 054-063.
Emmanuel, T.E., Godwin, I.G., Emmanuel, S.O. and Hope, C. (2023). Assessment of some toxicoinflammatory, hepato-renal and cardio-oxidative stress biomarkers among waste pickers
in Ajegunle Lagos State Nigeria. GSC Advanced Research and Reviews. 16(03), 111-
119.
Emmanuel, T.E., Ikhide, G.I. and Prudence, N.O. (2021). Abuse of alabukun consumption: A
biochemical and histomorphological study in Rattus norvegicus rats. World Journal of
Biology Pharmacy and Health Sciences. 08(01), 037-042.
Emmanuel, T.E., Ikhide, G.I. and Sonia, O.A. (2020). Biochemical and histomorphological
changes in liver and kidney of Rattus norvegicus domestica rats following tetracycline
administration. GSC Biological and Pharmaceutical Sciences. 12(02), 238-245.
George, M. I. and Adegoke, O.A. (2011). Effect of vitamin E on biochemical parameters in albino
rats treated with gasoline. Journal of Scientific Research. 3(3), 641-649.
Jamella, M. C. and Xin, X. (2010). Liver Function. Clinical Chemistry: Techniques, Principles,
Correlations. 6th edition. Lippincott. Williams and Wilkins Baltimore, p.788.
Mansour, R. A., Zahra, N. K., Farid, Z., Sousan, S. and Seyedi, M.D. (2012). Occupational
exposure of petroleum depot workers to BTEX compound. International Journal of
Occupational Environmental Medicine. 3 (1), 39-44.
Mohammed, A. and Samar, A. (2021). Evaluation of some biological parameters of gasoline
station attendants in Damascus Syria. Hellyon. 7(5), e07056.
Ndubuisi, ET.I. (2016). Haematological indicators of exposure to petroleum products in petroleum
refining and distribution industry workers in Nigeria. Journal of Clinical Toxicology.
6(1), 1-13.
Ola-EL-Kheir, E., Selma, A. and Naser, E.S. (2016). Early renal dysfunction is associated with
exposure to petroleum products in petrol stations workers at Khartoum State Sudan.
Scholars Journal of Applied Medical Sciences. 4(8B), 2853-2857.Serekara, G.C., Ibioku, E., Uchechukwu, A.O, and Constancy, P.A (2016). Effect of petroleum on
haematological parameters and lead level in fuel attendants in Port Harcourt, Nigeria.
International Journal of Science and Research. 5(3), 280-283.
Wesley, A., Natasha, D., Daniel, W.R., Daniel, J.C., James, P.M., Sanjay, S., Zhenazhi, X., Shesh,
R., Aruni, B. and Timothy, E.O. (2017). Benzene exposure is associated with
cardiovascular disease risk. PLoS One. 12(9), e0183602.
World Medical Association Declaration of Helsinki - Ethical Principles for Medical Research
Involving Human Subjects Adopted by the 59th World Medical Association General
Assembly, Seoul, Republic of Korea, October, 2008.

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