IIARD International Institute of Academic Research and Development

INTERNATIONAL JOURNAL OF CHEMISTRY AND CHEMICAL PROCESSES (IJCCP )

E-I SSN 2545-5265
P- ISSN 2695-1916
VOL. 9 NO. 1 2023
DOI: https://doi.org/10.56201/ijccp.v9.no1.2023.pg44.47

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Green Synthesis of Pyrazole Derivatives employing 1,3-Dipolar Cycloaddition Reaction using Phenyl hydrazones and Benzoquinone under basic condition

B.B.Bahule, R.R. Sangpal, Shital Jagtap, Rutuja Sawane, Shubhangi Dorage

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Abstract

The present study depicts the green synthesis of different Pyrazole derivatives from Phenyl hydrazones. The 1,3-dipolar cycloaddition reaction of Phenyl hydrazones with Benzoquinone is carried out under mild basic condition using bases like Pyridine and Triethyl amine. The reaction is conducted at room temperature so the unwanted by products are not formed. The work-up is also easy and can be accomplished by pouring the reaction mixture on ice and filtration of the solid product formed in the reaction. The crude products are further purified by the Column chromatography or recrystallisation techniques. The purified products are characterized by IR and 1H NMR spectroscopy

keywords:

Cycloaddition, Benzoquinone, Phenyl hydrazones, Triethyl amine, Pyridine

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